High efficacy of anti DBL4ɛ-VAR2CSA antibodies in inhibition of CSA-binding Plasmodium falciparum-infected erythrocytes from pregnant women

Malaria during pregnancy is a major cause of intra-uterine growth-retardation and infant death in sub-Saharan Africa. Ideally, this could be prevented by a vaccine delivered before the first pregnancy. Antibodies against domain DBL4ɛ from VAR2CSA has been shown to inhibit adhesion of laboratory isol...

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Bibliographic Details
Published in:Vaccine 2011-01, Vol.29 (3), p.437-443
Main Authors: Magistrado, Pamela A., Minja, Daniel, Doritchamou, Justin, Tuikue Ndam, Nicaise, John, Davis, Schmiegelow, Christentze, Massougbodji, Achille, Dahlbäck, Madeleine, Ditlev, Sisse B., Pinto, Vera V., Resende, Mafalda, Lusingu, John, Theander, Thor G., Salanti, Ali, Nielsen, Morten A.
Format: Article
Language:English
Subjects:
adhesion
Africans
antibodies
Antibodies, Protozoan - immunology
Antigens, Protozoan - immunology
Benin
Cell Adhesion
chondroitin sulfate
death
DNA Repair Enzymes - metabolism
erythrocytes
Erythrocytes - parasitology
Female
growth retardation
Humans
immunoglobulin G
Immunoglobulin G - immunology
malaria
Malaria Vaccines - immunology
Malaria, Falciparum - immunology
Placental malaria
Plasmodium
Plasmodium falciparum
Plasmodium falciparum - immunology
Pregnancy
Pregnancy Complications, Infectious - immunology
pregnant women
recombinant proteins
Recombinant Proteins - immunology
Tanzania
Transcription Factors - metabolism
Vaccine
vaccines
VAR2CSA
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Summary:Malaria during pregnancy is a major cause of intra-uterine growth-retardation and infant death in sub-Saharan Africa. Ideally, this could be prevented by a vaccine delivered before the first pregnancy. Antibodies against domain DBL4ɛ from VAR2CSA has been shown to inhibit adhesion of laboratory isolates to the placental receptor chondroitin sulfate A. In this study, the binding inhibitory efficacy of IgG elicited by two different DBL4ɛ recombinant proteins was tested on a panel of fresh clinical isolates from pregnant women living in Benin and Tanzania. The most promising recombinant protein elicited antibodies with similar efficacy as pooled plasma from immune multi-gravid African women.
ISSN:0264-410X
1873-2518
DOI:10.1016/j.vaccine.2010.10.080