Involvement of the AT₁ receptor in the venoconstriction induced by angiotensin II in both the inferior vena cava and femoral vein

Although angiotensin II-induced venoconstriction has been demonstrated in the rat vena cava and femoral vein, the angiotensin II receptor subtypes (AT₁ or AT₂) that mediate this phenomenon have not been precisely characterized. Therefore, the present study aimed to characterize the pharmacological r...

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Published in:Peptides (New York, N.Y. : 1980) N.Y. : 1980), 2011, Vol.32 (1), p.112-117
Main Authors: da Silva, Osmar Gomes, de Souza Rossignoli, Patrícia, Carrillo-Sepúlveda, Maria Alícia, Barreto-Chaves, Maria Luiza Morais, Chies, Agnaldo Bruno
Format: Article
Language:English
Subjects:
angiotensin II
Angiotensin II - pharmacology
Animals
Biological and medical sciences
Femoral Vein - drug effects
Fundamental and applied biological sciences. Psychology
Imidazoles - pharmacology
indomethacin
inferior vena cava
Losartan - pharmacology
Male
NG-Nitroarginine Methyl Ester - pharmacology
nitric oxide
prostaglandins
Pyridines - pharmacology
Rats
Receptor, Angiotensin, Type 1 - metabolism
receptors
Vasoconstriction - drug effects
Vasoconstriction - physiology
Vena Cava, Inferior - drug effects
Vertebrates: endocrinology
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Summary:Although angiotensin II-induced venoconstriction has been demonstrated in the rat vena cava and femoral vein, the angiotensin II receptor subtypes (AT₁ or AT₂) that mediate this phenomenon have not been precisely characterized. Therefore, the present study aimed to characterize the pharmacological receptors involved in the angiotensin II-induced constriction of rat venae cavae and femoral veins, as well as the opposing effects exerted by locally produced prostanoids and NO upon induction of these vasomotor responses. The obtained results suggest that both AT₁ and AT₂ angiotensin II receptors are expressed in both veins. Angiotensin II concentration–response curves were shifted toward the right by losartan but not by PD 123319 in both the vena cava and femoral vein. Moreover, it was observed that both 10⁻⁵M indomethacin and 10⁻⁴M L-NAME improve the angiotensin II responses in the vena cava and femoral vein. In conclusion, in the rat vena cava and femoral vein, angiotensin II stimulates AT₁ but not AT₂ to induce venoconstriction, which is blunted by vasodilator prostanoids and NO.
ISSN:0196-9781
1873-5169
DOI:10.1016/j.peptides.2010.10.010