Allele distribution of six STR/miniSTR loci (CD4, FABP2, D12S391, D14S1434, D22S1045 and D10S1248) for forensic purposes in Southeastern Brazil

Background: Allele frequencies for six STR/miniSTR loci were determined in a sample of unrelated individuals from Southeastern Brazil.Methods and results: No significant deviations from Hardy-Weinberg equilibrium proportions were observed for the loci investigated (p-values ≥ 0.2320). Statistical pa...

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Bibliographic Details
Published in:Annals of human biology 2011-01, Vol.38 (1), p.110-113
Main Authors: Santos, Luciana Lara dos, de Assis, Joana Bernardes, Reis, Adriana Helena de Oliveira, Scliar, Marília de Oliveira, Carvalho, Maria Raquel Santos, Vaintraub, Marco Túlio, Vaintraub, Patrícia
Format: Article
Language:English
Subjects:
Alleles
Base Sequence
Brazil
CD4 Antigens - genetics
DNA Fingerprinting
Fatty Acid-Binding Proteins - genetics
Forensic Genetics
Gene Frequency
Genetic Markers
Humans
Microsatellite Repeats
Paternity
Polymerase Chain Reaction
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Summary:Background: Allele frequencies for six STR/miniSTR loci were determined in a sample of unrelated individuals from Southeastern Brazil.Methods and results: No significant deviations from Hardy-Weinberg equilibrium proportions were observed for the loci investigated (p-values ≥ 0.2320). Statistical parameters of forensic interest such as heterozygosity (H), power of discrimination (PD) and power of exclusion (PE) were estimated. Except for marker FABP2, all STR/miniSTRs tested showed observed heterozygosities over 0.66.Combined power of discrimination and power of exclusion were 0.9999993 and 0.9925, respectively.Conclusions: Due to their ease of analysis and high informativity, these new STR multiplexes will be useful for extending current marker sets for forensic and paternity purposes.
ISSN:0301-4460
1464-5033
DOI:10.3109/03014460.2010.491488