Thyroglobulin gene is associated with premature ovarian failure

Variants of the thyroglobulin gene were significantly associated with premature ovarian failure in a Korean population. Three single nucleotide polymorphisms and one haplotype were found to be associated with a significant increase in the risk for premature ovarian failure.

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Bibliographic Details
Published in:Fertility and sterility 2011, Vol.95 (1), p.397-400
Main Authors: Pyun, Jung-A., M.S, Kang, HyunJun, M.S, Kim, JiHye, B.S, Cha, Dong Hyun, M.D., Ph.D, Kwack, KyuBum, Ph.D
Format: Article
Language:English
Subjects:
Adult
Asian Continental Ancestry Group - genetics
Biological and medical sciences
Diseases of mother, fetus and pregnancy
Female
Gene Frequency
genes
Gynecology. Andrology. Obstetrics
Haplotypes
Humans
Hypothyroidism - epidemiology
Hypothyroidism - genetics
Internal Medicine
Medical sciences
Obstetrics and Gynecology
polymorphism
Polymorphism, Single Nucleotide
Pregnancy. Fetus. Placenta
premature ovarian failure
Primary Ovarian Insufficiency - epidemiology
Primary Ovarian Insufficiency - genetics
risk
Risk Factors
single nucleotide polymorphism
Thyroglobulin
Thyroglobulin - genetics
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Description
Summary:Variants of the thyroglobulin gene were significantly associated with premature ovarian failure in a Korean population. Three single nucleotide polymorphisms and one haplotype were found to be associated with a significant increase in the risk for premature ovarian failure.
ISSN:0015-0282
1556-5653
DOI:10.1016/j.fertnstert.2010.08.038