Effects of Low-Dose γ-Irradiation on the Counts of Immunocompetent Cells in a Model Experiment on Primates

Cellular immunity was studied by flow cytometry with Becton Dickinson monoclonal antibodies in clinically healthy Macaca mulatta males before and after low-dose exposure to ionizing radiation. It was shown that T and B cells are radiosensitive, B cells being more sensitive, which is seen from a sign...

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Bibliographic Details
Published in:Bulletin of experimental biology and medicine 2010-12, Vol.150 (1), p.79-82
Main Authors: Ignatova, I. E, Agrba, V. Z, Lapin, B. A
Format: Article
Language:English
Subjects:
Animals
B-Lymphocytes - radiation effects
Biomedical and Life Sciences
Biomedicine
Cell Biology
Dose-Response Relationship, Radiation
Flow Cytometry
Gamma Rays - adverse effects
Internal Medicine
Killer Cells, Natural - radiation effects
Laboratory Medicine
low dose
Macaca mulatta - immunology
Male
Monoclonal antibodies
Nuclear radiation
Pathology
Primates
Primatology
T-Lymphocytes - radiation effects
γ-radiation
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Description
Summary:Cellular immunity was studied by flow cytometry with Becton Dickinson monoclonal antibodies in clinically healthy Macaca mulatta males before and after low-dose exposure to ionizing radiation. It was shown that T and B cells are radiosensitive, B cells being more sensitive, which is seen from a significant drop of their count. Natural killers are radioresistant. The count of immunocompetent cells recovers sooner after single compared to fractionated irradiation in the same summary dose.
ISSN:0007-4888
1573-8221
DOI:10.1007/s10517-010-1074-1