Depot-specific modulation of adipokine levels in rat adipose tissue by diet-induced obesity: The effect of aerobic training and energy restriction

The present study examined the effects of aerobic training and energy restriction on adipokines levels in mesenteric (MEAT) and retroperitoneal (RPAT) white adipose tissue from obese rats. Male Wistar rats were fed with standard laboratory diet (Control group) or high fat diet (HFD). After 15 weeks,...

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Bibliographic Details
Published in:Cytokine (Philadelphia, Pa.) Pa.), 2010-12, Vol.52 (3), p.168-174
Main Authors: Yamashita, Alex Shimura, Lira, Fábio Santos, Rosa, José Cesar, Paulino, Ellena Christina, Brum, Patrícia Chakur, Negrão, Carlos Eduardo, dos Santos, Ronaldo Vagner, Batista, Miguel Luiz, Oller do Nascimento, Claudia, Oyama, Lila Missae, Seelaender, Marília
Format: Article
Language:English
Subjects:
Adipokines
Adipokines - metabolism
Adiponectin - blood
Adipose Tissue - metabolism
Aerobic training
Animals
Body Weight
Energy Intake
Energy restriction
Linear Models
Male
Obesity - metabolism
Oxygen Consumption
Physical Conditioning, Animal
Rats
Rats, Wistar
White adipose tissue
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Summary:The present study examined the effects of aerobic training and energy restriction on adipokines levels in mesenteric (MEAT) and retroperitoneal (RPAT) white adipose tissue from obese rats. Male Wistar rats were fed with standard laboratory diet (Control group) or high fat diet (HFD). After 15 weeks, HFD rats were randomly assigned to the following groups: rats submitted to HFD, which were sedentary (sedentary HFD, n = 8) or trained (trained HFD, n = 8); or submitted to energy-restriction (ER), which were sedentary (sedentary ER, n = 8) or trained (trained ER, n = 8). Trained rats ran on a treadmill at 55% VO 2max for 60 min/day, 5 days/week, for 10 weeks. ER rats were submitted to a reduction of 20% daily caloric ingestion compared to the Control group. ER and aerobic training decreased body weight, MEAT and RPAT absolute weight, and fat mass. IL-6, IL-10 and TNF-α levels were decreased and adiponectin did not change in RPAT in response to ER protocol. On the other hand, ER and the aerobic training protocol decreased IL-6, TNF-α and adiponectin levels in MEAT. Absolute MEAT weight showed a positive correlation with IL-6 ( r = 0.464), TNF-α ( r = 0.508); and adiponectin ( r = 0.342). These results suggest a tissue-specific heterogeneous response in adipokines level. The combination of the protocols (aerobic training and energy restriction) did not induce an enhanced effect.
ISSN:1043-4666
1096-0023
DOI:10.1016/j.cyto.2010.07.006