Androgens and atrial fibrillation: Friends or foes?

Abstract Atrial fibrillation (AF) is the most common sustained arrhythmia encountered in clinical practice. The prevalence of AF increases with age, and this age-specific prevalence is higher in men than in women. However, the mechanisms of aging-induced AF have not been fully elucidated, and this m...

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Bibliographic Details
Published in:International journal of cardiology 2010-11, Vol.145 (2), p.365-367
Main Authors: Liu, Tong, Shehata, Michael, Li, Guangping, Wang, Xunzhang
Format: Article
Language:English
Subjects:
Age Factors
Anabolic Agents - adverse effects
Anabolic Agents - blood
Androgens
Androgens - blood
Androgens - therapeutic use
Atrial fibrillation
Atrial Fibrillation - blood
Atrial Fibrillation - prevention & control
Biological and medical sciences
Cardiac dysrhythmias
Cardiology. Vascular system
Cardiovascular
Female
Heart
Humans
Male
Medical sciences
Testosterone
Testosterone - blood
Testosterone - therapeutic use
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Summary:Abstract Atrial fibrillation (AF) is the most common sustained arrhythmia encountered in clinical practice. The prevalence of AF increases with age, and this age-specific prevalence is higher in men than in women. However, the mechanisms of aging-induced AF have not been fully elucidated, and this may be related to decline of testosterone with advancing age. On the other hand, anabolic steroid abuse may precipitate the occurrence of AF. Until now, the possible relationship between androgens and AF was not comprehensively reviewed. We intend to review some recent evidence on this issue and propose some potential mechanisms.
ISSN:0167-5273
1874-1754
DOI:10.1016/j.ijcard.2010.02.039