Factors Associated with Adherence to Guidelines for the Use of Tigecycline in a Tertiary Care Hospital

We assessed the adherence to the prescribing hospital protocol for tigecycline and factors associated with noncompliance. A total of 103 patients were included in the study. In 23 (22.3%) patients, tigecycline was not administered according to the protocol, mostly because of the availability of othe...

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Bibliographic Details
Published in:Journal of chemotherapy (Florence) 2010-10, Vol.22 (5), p.339-344
Main Authors: Grau, S., Conde-Estévez, D., Luque, S., Álvarez-Lerma, F., Horcajada, J.P., Mateu-De Antonio, J., Berenguer, N., Salas, E.
Format: Article
Language:English
Subjects:
Anti-Bacterial Agents - adverse effects
Anti-Bacterial Agents - therapeutic use
antibiotic usage
Antibiotics. Antiinfectious agents. Antiparasitic agents
antimicrobial stewardship
audit
Bacterial Infections - drug therapy
beta-Lactam Resistance - genetics
Biological and medical sciences
Clinical Protocols
Community-Acquired Infections - drug therapy
Drug Hypersensitivity
Female
Guideline Adherence
Hospitals, University
Humans
Male
Medical Order Entry Systems
Medical sciences
Minocycline - adverse effects
Minocycline - analogs & derivatives
Minocycline - therapeutic use
Penicillins - adverse effects
Pharmacology. Drug treatments
Practice Guidelines as Topic
protocol
Retrospective Studies
Tigecycline
Treatment Outcome
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Summary:We assessed the adherence to the prescribing hospital protocol for tigecycline and factors associated with noncompliance. A total of 103 patients were included in the study. In 23 (22.3%) patients, tigecycline was not administered according to the protocol, mostly because of the availability of other therapeutic alternatives and prescription for indications that were not included in the guidelines. Factors independently associated with nonadherence to the protocol were community-acquired infection (OR, 14.01; 95% CI, 1.54-127.12; P=0.019), and empirical tigecycline treatment (OR, 6.97; 95% Ci, 0.88- 55.40; P=0.066). Penicillin allergy (OR, 0.004; 95% CI, 0.000-0.071; P=0.001) and previous antibiotic treatment (OR, 0.025; 95% CI, 0.003-0.233; P=0.001) were factors associated with adherence to the hospital protocol. A positive time trend between total number of prescriptions and non-compliant prescriptions with the protocol was observed (Spearman's rho coefficient 0.971; P=0.001). Adherence to tigecycline protocol could be improved by focusing on protocols for community-acquired infections, mainly skin and soft tissue infections.
ISSN:1120-009X
1973-9478
DOI:10.1179/joc.2010.22.5.339