Intralesional injection of triamcinolone hexacetonide as an alternative treatment for central giant-cell granuloma in 21 cases

Abstract Central giant-cell granulomas are benign, but occasionally aggressive, lesions that traditionally have been treated surgically. 21 cases of central giant-cell granuloma of the jaw were treated with intralesional injection of corticosteroids. The treatment protocol adopted was intralesional...

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Bibliographic Details
Published in:International journal of oral and maxillofacial surgery 2010-12, Vol.39 (12), p.1204-1210
Main Authors: Nogueira, R.L.M, Teixeira, R.C, Cavalcante, R.B, Ribeiro, R.A, Rabenhosrt, S.H.B
Format: Article
Language:English
Subjects:
Adolescent
Adult
Anti-Inflammatory Agents - administration & dosage
Biological and medical sciences
Bones, joints and connective tissue. Antiinflammatory agents
central giant-cell granuloma
Child
Child, Preschool
corticosteroids
Dentistry
Dermatology
Female
Glucocorticoids - administration & dosage
Granuloma, Giant Cell - drug therapy
Humans
injection
Injections, Intralesional
Jaw Diseases - drug therapy
Male
Medical sciences
Otorhinolaryngology. Stomatology
Pharmacology. Drug treatments
Skin involvement in other diseases. Miscellaneous. General aspects
Surgery
Triamcinolone Acetonide - administration & dosage
Triamcinolone Acetonide - analogs & derivatives
triamcinolone hexacetonide
Young Adult
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Summary:Abstract Central giant-cell granulomas are benign, but occasionally aggressive, lesions that traditionally have been treated surgically. 21 cases of central giant-cell granuloma of the jaw were treated with intralesional injection of corticosteroids. The treatment protocol adopted was intralesional injection of 20 mg/ml triamcinolone hexacetonide diluted in an anaesthetic solution of 2% lidocaine/epinephrine 1:200,000 in the proportion 1:1; 1.0 ml of the solution was infiltrated for every 1 cm3 of radiolucid area of the lesion, totalling 6 biweekly applications. Ten patients had aggressive lesions and 11 nonaggressive. Two patients showed a negative response to the treatment and underwent surgical resection, 4 showed a moderate response and 15 a good response. 8 of the 19 who had a moderate-to-good response to the drug treatment underwent osteoplasty to reestablish facial aesthetics. In these cases, only mature or dysplastic bone was observed, with the presence or absence of rare giant multinucleated cells. The advantages of this therapy are its less-invasive nature, the probable lower cost to the patient, lower risk and the ability to treat the lesion surgically in the future, if necessary.
ISSN:0901-5027
1399-0020
DOI:10.1016/j.ijom.2010.06.015