Effect of Age and Sex on Blood Pressure, Development of Renal Hypertension, and Concentration of Nitric Oxide in the Blood of Albino Rats

The mean blood pressure did not depend on the sex of animals and was characterized by the same ontogenetic changes in males and females. The mean blood pressure in infantile and, particularly, in old rats was higher than in adult animals. The increase in blood pressure in old rats was accompanied by...

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Published in:Bulletin of experimental biology and medicine 2010-07, Vol.149 (1), p.1-3, Article 1
Main Authors: Anishchenko, T. G, Semyachkina-Glushkovskaya, O. V, Berdnikova, V. A, Sindyakova, T. A
Format: Article
Language:eng ; rus
Subjects:
age
Age Factors
Aging - physiology
Analysis of Variance
Animals
Biomedical and Life Sciences
Biomedicine
Blood pressure
Blood Pressure - physiology
Cell Biology
Female
Hypertension, Renal - etiology
Hypertension, Renal - physiopathology
Internal Medicine
Laboratory Medicine
Male
Nitric oxide
Nitric Oxide - blood
Pathology
Physiology
Rats
Renal hypertension
sex
Sex Factors
Statistics, Nonparametric
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Summary:The mean blood pressure did not depend on the sex of animals and was characterized by the same ontogenetic changes in males and females. The mean blood pressure in infantile and, particularly, in old rats was higher than in adult animals. The increase in blood pressure in old rats was accompanied by a decrease in NO production. Infantile rats were least resistant to the development of renal hypertension. The degree of hypertension in infantile and adult females was lower than in males. However, the concentration of NO in these females was higher than in male rats. Aging was accompanied by inversion of sex differences in the resistance to renal hypertension. The severity of hypertension in old females was greater than in males. It was accompanied by a signifi cant age-related decrease in NO concentration in female animals. Our results indicate that NO plays an important role in sex differences in the resistance of infantile, adult, and old rats to hypertension, while the decrease in NO concentration during aging leads to blood pressure elevation in females and males.
ISSN:0007-4888
1573-8221
DOI:10.1007/s10517-010-0859-6