Topical acetylcholine applications: Electrocortical-behavioral correlations

The electrophysiological and behavioral responses of chronically cannulated squirrel monkeys were examined following the topical application of acetylcholine to the cerebral cortex. Several combinations of spike and/or slow-wave patterns were observed. Gross behaviors (e.g. orientation) were little...

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Bibliographic Details
Published in:	Physiology & behavior 1971-06, Vol.6 (6), p.739-742
Main Authors:	Fleming, Donovan E., Wilson, Charles E., Rhodes, Leland E.
Format:	Article
Language:	eng
Subjects:	Acetylcholine Acetylcholine - administration & dosage Acetylcholine - pharmacology Animals Attention Attentional shift Avoidance Learning Avoidance responses Behavior, Animal - drug effects Cerebral Cortex - drug effects Conditioning (Psychology) Cortical paroxysms Disease Models, Animal Electroencephalography Epilepsy Haplorhini Motor Activity Orientation
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Summary:	The electrophysiological and behavioral responses of chronically cannulated squirrel monkeys were examined following the topical application of acetylcholine to the cerebral cortex. Several combinations of spike and/or slow-wave patterns were observed. Gross behaviors (e.g. orientation) were little affected by the cortical paroxysmal discharges. Performance on a conditioned avoidance task utilizing a short CS-US interval was debilitated by the cortical discharges. On an avoidance task utilizing a longer CS-US interval only repetitive spike discharges produced a behavioral deficit. It was suggested that the cortical discharges are disruptive to motor and/or attentional processes which result in an increase in the time required to coordinate and emit the conditioned response.
ISSN:	0031-9384 1873-507X