Involvement of Autoimmunity in the Pathogenesis of Aggressive Periodontitis

The aim of this study was to investigate the involvement of autoimmune reactions to native and post-translationally modified extracellular matrix components in the pathogenesis of periodontitis. Sera from individuals with aggressive periodontitis (AgP, n = 25), chronic periodontitis (CP, n = 14), an...

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Bibliographic Details
Published in:Journal of dental research 2010-12, Vol.89 (12), p.1389-1394
Main Authors: Hendler, A., Mulli, T.K., Hughes, F.J., Perrett, D., Bombardieri, M., Houri-Haddad, Y., Weiss, E.I., Nissim, A.
Format: Article
Language:English
Subjects:
Adult
Aggressive Periodontitis - blood
Aggressive Periodontitis - immunology
Autoantibodies
Autoantibodies - blood
Autoantigens - immunology
Autoimmunity - immunology
Biological and medical sciences
Chronic Periodontitis - blood
Chronic Periodontitis - immunology
Citrulline - immunology
Collagen Type I - immunology
Collagen Type III - immunology
Dentistry
Electrophoresis, Polyacrylamide Gel
Extracellular Matrix - immunology
Facial bones, jaws, teeth, parodontium: diseases, semeiology
Female
Fluorescence
Gingivitis - blood
Gingivitis - immunology
Humans
Hydroxyl Radical - pharmacology
Hypochlorous Acid - pharmacology
Imaging, Three-Dimensional
Intermediate Filament Proteins - immunology
Male
Medical sciences
Middle Aged
Nitrates - pharmacology
Non tumoral diseases
Otorhinolaryngology. Stomatology
Oxidants - pharmacology
Phosphoproteins - immunology
Protein Precursors - immunology
Protein Processing, Post-Translational - immunology
Reactive Oxygen Species - immunology
Young Adult
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Summary:The aim of this study was to investigate the involvement of autoimmune reactions to native and post-translationally modified extracellular matrix components in the pathogenesis of periodontitis. Sera from individuals with aggressive periodontitis (AgP, n = 25), chronic periodontitis (CP, n = 14), and gingivitis (G, n = 18) were tested for the presence of autoantibodies against: (a) native collagen type I (CI) and collagen type III (CIII); (b) CI and CIII post-translationally modified by reactive oxygen species (ROS) of the type present during inflammation; and (c) citrullinated filaggrin-derived peptides (CCP). Autoantibodies to native and ROS-modified CI and CIII as well as autoantibodies to CCP were observed exclusively in patients with AgP and not in those with CP or G. In conclusion, autoimmune reactions to native and post-translationally modified self-antigens may play a role specifically in the pathogenesis of AgP.
ISSN:0022-0345
1544-0591
1544-0591
DOI:10.1177/0022034510381903