Lack of correlation between the presence of circulating tumor cells and the development of pulmonary metastases

Sarcoma 1 implanted on the feet of A/jax mice metastasizes to lymph nodes and only rarely to lungs. Between days 7 and 14, there were enough tumor cells present in the circulating blood or lungs to enable the tumor to be transferred by injecting either blood or lung tissue into the thighs of other m...

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Bibliographic Details
Published in:Cancer 1971-09, Vol.28 (3), p.655-656
Main Authors: Crile, George, Isbister, William, Deodhar, S. D.
Format: Article
Language:English
Subjects:
Amputation
Animals
Hindlimb
Lung Neoplasms - physiopathology
Male
Mice
Neoplasm Metastasis - physiopathology
Neoplasm Transplantation
Neoplastic Cells, Circulating - physiopathology
Sarcoma, Experimental - physiopathology
Time Factors
Citations: Items that this one cites
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Summary:Sarcoma 1 implanted on the feet of A/jax mice metastasizes to lymph nodes and only rarely to lungs. Between days 7 and 14, there were enough tumor cells present in the circulating blood or lungs to enable the tumor to be transferred by injecting either blood or lung tissue into the thighs of other mice. Despite the presence of tumor cells in both blood and lungs, pulmonary metastases were rarely seen in mice who died as a result of the primary tumor and its nodal metastases.
ISSN:0008-543X
1097-0142
DOI:10.1002/1097-0142(197109)28:3<655::AID-CNCR2820280318>3.0.CO;2-4