Adrenalectomy abolishes the stress-induced increase in pituitary cyclic AMP

We have previously demonstrated that various stressors increase pituitary cyclic AMP in vivo in the rat. In the course of studying the mechanisms mediating this response, we examined the effect of bilateral adrenalectomy on footshock-induced increases in pituitary cyclic AMP. In unoperated rats, int...

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Bibliographic Details
Published in:	Life sciences (1973) 1984-05, Vol.34 (20), p.1959-1965
Main Authors:	Meyerhoff, James L., Jean Kant, G., Nielsen, Carl J., Mougey, Edward H.
Format:	Article
Language:	eng
Subjects:	Adrenalectomy Adrenals. Interrenals Adrenocorticotropic Hormone - metabolism Animals beta-Endorphin Biological and medical sciences Corticotropin-Releasing Hormone - pharmacology Cyclic AMP - analysis Electroshock Endorphins - metabolism Fundamental and applied biological sciences. Psychology Male Morphology. Functional localizations Pituitary Gland - analysis Rats Rats, Inbred Strains Stress, Physiological - metabolism Vertebrates: endocrinology
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Summary:	We have previously demonstrated that various stressors increase pituitary cyclic AMP in vivo in the rat. In the course of studying the mechanisms mediating this response, we examined the effect of bilateral adrenalectomy on footshock-induced increases in pituitary cyclic AMP. In unoperated rats, intermittent footshock markedly increased pituitary levels of cyclic AMP and plasma levels of corticosterone and prolactin. Adrenalectomy completely abolished the stress-induced increase in pituitary cyclic AMP. The marked increase in plasma prolactin following footschock was not affected by adrenalectomy. Our results indicate that adrenal factors are involved in the stress-induced increase in pituitary cyclic AMP.
ISSN:	0024-3205 1879-0631