Osmoregulation and renal effects of vasopressin in normal and mildly hypertensive subjects

Osmoregulation and renal effects of vasopressin in normal and mildly hypertensive subjects. A 2-hr 0.85 M hypertonic saline infusion was administered to ten normotensive volunteers and ten mildly hypertensive subjects to compare in these two groups the osmoregulation of vasopressin and the effect of...

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Published in:Kidney international 1984-02, Vol.25 (2), p.411-415
Main Authors: Thibonnier, Marc, Sassano, Paolo, Daufresne, Sylvie, Corvol, Pierre, Menard, Joel
Format: Article
Language:English
Subjects:
Adult
Arginine Vasopressin - blood
Arginine Vasopressin - physiology
Arginine Vasopressin - urine
Blood Pressure
Female
Humans
Hypertension - blood
Hypertension - physiopathology
Male
Middle Aged
Osmolar Concentration
Saline Solution, Hypertonic
Water-Electrolyte Balance
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Summary:Osmoregulation and renal effects of vasopressin in normal and mildly hypertensive subjects. A 2-hr 0.85 M hypertonic saline infusion was administered to ten normotensive volunteers and ten mildly hypertensive subjects to compare in these two groups the osmoregulation of vasopressin and the effect of this hormone on BP. No significant alteration in BP was observed in either group, despite markedly enhanced vasopressin levels. Significant positive correlations between plasma vasopressin (AVP) and plasma osmolality (POsm) were demonstrated in the controls (AVP = -70 + 0.25 POsm, r = 0.68, P < 0.0001) and in the hypertensive group (AVP = -46 + 0.16 POsm, r = 0.59, P < 0.0001). However, the vasopressin response to the osmotic stimulus was buffered in the hypertensive subjects; the slope of the regression line between plasma vasopressin and plasma osmolality was less steep in hypertensive subjects than in normotensive subjects (0.16 vs. 0.25, P < 0.018). During the saline infusion the renal parameters were identical in the two groups. Finally, in mild hypertension, the osmoregulation of vasopressin was preserved but buffered and renal sensitivity to this hormone was normal. An osmotically induced physiological increase in vasopressin did not raise BP in either normotensive or mildly hypertensive subjects. Osmorégulation et effets rénaux de la vasopressine chez des sujets normaux et modérément hypertendus. Une perfusion de 2 heures de soluté salé hypertonique à 0,85M a été administrée à dix volontaires normotendus et dix sujets modérément hypertendus afin de comparer dans ces deux groupes l'osmorégulation de la vasopressine et l'effet de cette hormone sur la pression artérielle. Aucune altération significative de la pression artérielle n'a été observée dans chacun des groupes, malgré des niveaux de vasopressine stimulés de façon marquée. Des corrélations positives significatives entre la vasopressine plasmatique (AVP) et l'osmolalité plasmatique (POsm) ont été démontrées chez les contrôles (AVP = -70 + 0,25 POsm, r = 0,68, P < 0,0001) et dans le groupe hypertendu (AVP = -46 + 0,16 POsm, r = 0,59, P < 0,0001). Cependant, la réponse de la vasopressine au stimulus osmotique était amortie chez les sujets hypertendus; la pente de la droite de régression entre la vasopressine plasmatique et l'osmolalité plasmatique était moins forte chez les sujets hypertendus que chez les sujects normotendus (0,16 contre 0,25, P < 0,018). Pendant la perfusion de soluté salé, les param
ISSN:0085-2538
1523-1755
DOI:10.1038/ki.1984.32