Serratia Marcescens Meningitis Associated with a Contaminated Benzalkonium Chloride Solution

Serratia marcescens is recognized as an important and potentially hazardous nosocomial pathogen. The organism has been implicated here as the first reported case of S. marcescens meningitis associated with skin disinfection. A quaternary ammonium compound (QAC-Benzalkonium Chloride), was used to ste...

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Bibliographic Details
Published in:Infection control : IC 1984-05, Vol.5 (5), p.223-225
Main Authors: Sautter, Robert L., Mattman, L. H., Legaspi, Ruben C.
Format: Article
Language:English
Subjects:
Antiseptics
Benzalkonium compounds
Benzalkonium Compounds - pharmacology
Bottles
Chlorides
Disinfectants
Drug Contamination
Enterobacteriaceae Infections - etiology
Female
Health hazards
Humans
Infections
Meningitis
Meningitis - etiology
Middle Aged
Nursing
Pathogens
Quaternary ammonium compounds
Serratia marcescens
Serratia marcescens - drug effects
Serratia marcescens - isolation & purification
Skin - microbiology
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Summary:Serratia marcescens is recognized as an important and potentially hazardous nosocomial pathogen. The organism has been implicated here as the first reported case of S. marcescens meningitis associated with skin disinfection. A quaternary ammonium compound (QAC-Benzalkonium Chloride), was used to sterilize the skin prior to injection in a physician's office. Epidemiological studies were initiated. Six spray bottles containing disinfectant, the opened stock bottle of QAC, and an unopened bottle of disinfectant were all cultured. S. marcescens was noted growing in the spray bottles as well as in the opened stock bottle. Antibiograms of the patient and epidemiological isolates are essentially the same. It is our contention as well as that of the Centers for Disease Control that an appropriate skin disinfectant such as Tincture of Chlorhexidine, Iodophors, or Tincture of Iodine should be used, and that physicians performing surgical techniques in the office be aware of the potential hazard of contamination. The consequences of nosocomial infection with resistant organisms warrant every precaution by health care professionals.
ISSN:0195-9417
2327-9451
DOI:10.1017/S019594170006015X