Electron Microscopical Studies of Strongyloides ratti Infective Larvae: Loss of the Surface Coat during Skin Penetration

Previous indications using radiolabelled larvae that Strongyloides ratti free-living infective larvae lose a surface coat during penetration of the skin were further investigated by transmission electron microscopy of the cuticle of S. ratti infective larvae in the free-living stage, after penetrati...

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Bibliographic Details
Published in:The Journal of parasitology 1987-10, Vol.73 (5), p.1030-1034
Main Authors: Grove, David I., Warton, Andrzej, Northern, Carolyn, Papadimitriou, John M.
Format: Article
Language:English
Subjects:
Animal cuticle
Animals
Biological and medical sciences
Female
Fundamental and applied biological sciences. Psychology
Invertebrates
Larvae
Larval development
Lungs
Mice
Mice, Inbred C57BL
Microscopy
Microscopy, Electron
Morphology. Histology. Cytology
Nemathelminthia. Plathelmintha
Nematode larvae
Nematodes
Parasitology
Rats
Rats, Inbred Strains
Skin
Skin - parasitology
Strongyloides - physiology
Strongyloides - ultrastructure
Strongyloidiasis - parasitology
Ultrastructure
Worms
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Summary:Previous indications using radiolabelled larvae that Strongyloides ratti free-living infective larvae lose a surface coat during penetration of the skin were further investigated by transmission electron microscopy of the cuticle of S. ratti infective larvae in the free-living stage, after penetration of mouse skin, and after migration to the lungs. These studies demonstrated the presence of a faint electron-dense surface coat external to the epicuticle on free-living worms which was absent from larvae recovered from the skin and lungs. When free-living infective larvae were incubated in 10% CO2 at 37 C and then examined with phase-contrast microscopy, worms were observed in the process of losing this coat. These observations confirm the hypothesis that S. ratti infective larvae lose a surface coat during penetration of the skin.
ISSN:0022-3395
1937-2345
DOI:10.2307/3282528