Retinoblastoma Metastatic to Bone Marrow: A Case with Florid Spread

A 28-month-old white male, 7 months status postenucleation for retinoblastoma, presented with lethargy, irritability, anemia, and thrombocytopenia. Bone marrow examination revealed almost total replacement of marrow elements with clumps of small round basophilic cells. Electron microscopic study of...

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Bibliographic Details
Published in:Clinical pediatrics 1984-03, Vol.23 (3), p.184-187
Main Authors: Friedman, Henry S., Kurtzberg, Joanne, Croker, Byron, Falletta, John M., Kinney, Thomas R.
Format: Article
Language:English
Subjects:
Biological and medical sciences
Bone Marrow - ultrastructure
Bone Neoplasms - secondary
Child, Preschool
Combined Modality Therapy
Eye Neoplasms - ultrastructure
Hematologic and hematopoietic diseases
Humans
Male
Medical sciences
Ophthalmology
Other diseases. Hematologic involvement in other diseases
Retinoblastoma - secondary
Retinoblastoma - therapy
Retinoblastoma - ultrastructure
Tumors and pseudotumors of the eye, orbit, eyelid, lacrimal apparatus
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Summary:A 28-month-old white male, 7 months status postenucleation for retinoblastoma, presented with lethargy, irritability, anemia, and thrombocytopenia. Bone marrow examination revealed almost total replacement of marrow elements with clumps of small round basophilic cells. Electron microscopic study of the marrow revealed clumps of cohesive tumor cells with intermediate junctions, establishing a diagnosis of metastatic retinoblastoma.
ISSN:0009-9228
1938-2707
DOI:10.1177/000992288402300312