Differential peripheral nerve block by local anesthetics in the cat

Controversy still surrounds the differential susceptibility of nerve fibers to local anesthetic conduction block. In order to help resolve this controversy, we developed an in vivo model of peripheral nerve blockade in the cat that closely reproduced the clinical state. Using this model, differentia...

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Bibliographic Details
Published in:Anesthesiology (Philadelphia) 1984, Vol.60 (1), p.28-33
Main Authors: FORD, D. J, PRITHVI RAJ, P, PRITAM SINGH, REGAN, K. M, OHLWEILER, D
Format: Article
Language:English
Subjects:
Action Potentials
Anesthetics, Local
Anesthetics. Neuromuscular blocking agents
Animals
Biological and medical sciences
Bupivacaine
Cats
Electric Stimulation
Etidocaine
Lidocaine
Medical sciences
Nerve Block
Nerve Fibers - drug effects
Nerve Fibers, Myelinated - drug effects
Neuropharmacology
Peripheral Nerves - drug effects
Pharmacology. Drug treatments
Procaine - analogs & derivatives
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Summary:Controversy still surrounds the differential susceptibility of nerve fibers to local anesthetic conduction block. In order to help resolve this controversy, we developed an in vivo model of peripheral nerve blockade in the cat that closely reproduced the clinical state. Using this model, differential rate of nerve blockade of A-alpha, A-delta, and C fibers by 2-chloroprocaine, lidocaine, bupivacaine, and etidocaine was observed and quantitated. C fibers were blocked first by 2-chloroprocaine, lidocaine and bupivacaine. Etidocaine blocked A-delta fibers first. A-alpha fibers always were blocked last. Of the four local anesthetics tested, 2-chloroprocaine produced the greatest differential rate of block of the nerve fibers, and etidocaine produced the least.
ISSN:0003-3022
1528-1175
DOI:10.1097/00000542-198401000-00007