Nicotine gum in smoking cessation: A placebo-controlled, double-blind trial

Sixty subjects were run in a study comparing the use of nicotine gum with placebo gum during cessation from smoking. Subjects were given clinic support and chewed the gum ad libitum. A survival analysis showed the two groups differed significantly in successful abstinence over time ( p < .03). Di...

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Bibliographic Details
Published in:Addictive behaviors 1983, Vol.8 (3), p.253-261
Main Authors: Schneider, Nina G., Jarvik, Murray E., Forsythe, Alan B., Read, Laura L., Elliott, Mark L., Schweiger, Avraham
Format: Article
Language:English
Subjects:
Addictive behaviors
Administration, Oral
Adult
Adult and adolescent clinical studies
Biological and medical sciences
Double-Blind Method
Female
Follow-Up Studies
Humans
Male
Medical sciences
Nicotine - administration & dosage
Psychology. Psychoanalysis. Psychiatry
Psychopathology. Psychiatry
Smoking Prevention
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Summary:Sixty subjects were run in a study comparing the use of nicotine gum with placebo gum during cessation from smoking. Subjects were given clinic support and chewed the gum ad libitum. A survival analysis showed the two groups differed significantly in successful abstinence over time ( p < .03). Differences between groups appeared early (within weeks) and, at six months, a 28% superiority of nicotine over placebo gum was demonstrated with mean success rates of 48% and 20%, respectively. Between six months and one year, relapse in the nicotine group accounted for the 30% vs. 20% success rates for nicotine and placebo observed at one year. In a pilot study (“dispensary”) testing the efficacy of the two gums when intervention was minimal, subjects in both groups resumed smoking within the first two weeks. The enhanced short-term success rates with nicotine gum in the clinic study are attributed to an effective interaction between use of the active preparation and clinic support. Long-term cessation may require extended maintenance procedures and/or an identification of optimal gum use.
ISSN:0306-4603
1873-6327
DOI:10.1016/0306-4603(83)90020-5