antiviral compound HPA-23 can prevent scrapie when administered at the time of infection

The effects of up to 12 daily doses of HPA-23 (ammonium 5-tungsto-2-antimoniate) on scrapie were studied using five experimental models of the disease, some with widely different incubation times. Treatment of animals with HPA-23, starting just before injecting scrapie, produced survivors. In some e...

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Bibliographic Details
Published in:Archives of virology 1983-01, Vol.78 (1/2), p.9-18
Main Authors: Kimberlin, R.H, Walker, C.A
Format: Article
Language:English
Subjects:
animal diseases
animal health
Animals
Antibiotics. Antiinfectious agents. Antiparasitic agents
Antimony - pharmacology
Antimony - therapeutic use
Antiviral agents
Antiviral Agents - therapeutic use
Biological and medical sciences
Cricetinae
Female
Medical sciences
Mesocricetus
Mice
Pharmacology. Drug treatments
Scrapie - prevention & control
Sheep
Tungsten - pharmacology
Tungsten - therapeutic use
Tungsten Compounds
viral diseases of animals and humans
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Summary:The effects of up to 12 daily doses of HPA-23 (ammonium 5-tungsto-2-antimoniate) on scrapie were studied using five experimental models of the disease, some with widely different incubation times. Treatment of animals with HPA-23, starting just before injecting scrapie, produced survivors. In some experiments, animals were fully protected against several hundred infectious units of scrapie. Treatment of animals after infection was far less effective. Prolonging the treatment for several weeks was no more effective than treating for a few days. In a very long incubation model of scrapie, the course of 12 daily doses of HPA-23 represented less than 3 per cent of the total incubation period. HPA-23 may interact with certain cells of the lymphoreticular system, preventing infection and, perhaps, the early replication of agent.
ISSN:0304-8608
1432-8798
DOI:10.1007/bf01310854