Localization of parathyroid hormone-related protein in breast cancer metastases : increased incidence in bone compared with other sites

Parathyroid hormone-related protein (PTHrP) has recently been identified in 60% of a series of primary breast cancers. The detection of a bone-resorbing factor in tumors with a propensity to metastasize to bone prompted study of PTHrP in breast cancer metastasis. PTHrP was localized by immunohistolo...

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Bibliographic Details
Published in:Cancer research (Chicago, Ill.) Ill.), 1991-06, Vol.51 (11), p.3059-3061
Main Authors: POWELL, G. J, SOUTHBY, J, DANKS, J. A, STILLWELL, R. G, HAYMAN, J. A, HENDERSON, M. A, BENNETT, R. C, MARTIN, T. J
Format: Article
Language:English
Subjects:
Biological and medical sciences
bone
Bone Neoplasms - chemistry
Bone Neoplasms - secondary
breast
Breast Neoplasms
carcinoma
Female
Gynecology. Andrology. Obstetrics
Humans
Mammary gland diseases
Medical sciences
Neoplasm Proteins - analysis
Parathyroid Hormone - analysis
Parathyroid Hormone-Related Protein
Proteins - analysis
Retrospective Studies
Tumors
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Summary:Parathyroid hormone-related protein (PTHrP) has recently been identified in 60% of a series of primary breast cancers. The detection of a bone-resorbing factor in tumors with a propensity to metastasize to bone prompted study of PTHrP in breast cancer metastasis. PTHrP was localized by immunohistology in 12 of 13 (92%) breast cancer metastases in bone and in 3 of 18 (17%) metastases in non-bone sites. The statistical difference was highly significant (P less than 0.0001). Production of PTHrP as a bone-resorbing agent may contribute to the ability of breast cancers to grow as bone metastases.
ISSN:0008-5472
1538-7445