Clinical trial of continuous infusion of alphaxalone/alphadolone in intensive care patients

The safety and efficacy of prolonged infusion of alphaxalone/alphadolone (Alfathesin: Glaxo) was assessed in 20 critically ill patients needing sedation during intermittent positive pressure ventilation in a general intensive care unit. The mean dose of Alfathesin infused was 1542 ml (range: 225 to...

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Bibliographic Details
Published in:Anaesthesia and intensive care 1983-05, Vol.11 (2), p.107-112
Main Authors: Stewart, G O, Dobb, G J, Craib, I A
Format: Article
Language:English
Subjects:
Adult
Aged
Anesthetics - administration & dosage
Cholesterol - blood
Clinical Trials as Topic
Drug Combinations
Electroencephalography
Female
Humans
Infusions, Parenteral
Intensive Care Units
Lipoproteins - blood
Male
Middle Aged
Pregnanediones - administration & dosage
Triglycerides - blood
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Summary:The safety and efficacy of prolonged infusion of alphaxalone/alphadolone (Alfathesin: Glaxo) was assessed in 20 critically ill patients needing sedation during intermittent positive pressure ventilation in a general intensive care unit. The mean dose of Alfathesin infused was 1542 ml (range: 225 to 4820 ml) over 6.9 days (3 to 16 days) at rates between 5 and 15 ml/hour. Significant increases in plasma urea, creatinine, bilirubin, alkaline phosphatase and white cell count occurred during the infusion, but these were expected from each patient's clinical course. Lipoprotein electrophoresis invariably showed loss of the alpha band and appearance of a densely staining pre-beta band. Four patients had involuntary movements during the infusion and two patients fitted when the infusion stopped. Both had cerebral injuries. Subjective assessment of the quality of sedation was "very good" or "good" in 15 patients and "fair" in five.
ISSN:0310-057X
1448-0271
DOI:10.1177/0310057X8301100203