Hepatitis B Virus Infection in Cultured Human Lymphoblastoid Cells

Since it has been postulated that liver hepatocytes may become infected by hepatitis B virus (HBV) in vivo through direct contact with infected macrophages, the possibility that a circulating cell of hematopoietic origin might be susceptible to infection with HBV was investigated. Cells positive for...

Full description

Saved in:

Bibliographic Details
Published in:	Science (American Association for the Advancement of Science) 1983-08, Vol.221 (4611), p.667-669
Main Authors:	Romet-Lemonne, Jean-Loup, McLane, Mary Frances, Elfassi, Emile, Haseltine, William A., Azocar, José, Essex, Myron
Format:	Article
Language:	eng
Subjects:	B lymphocytes Biological and medical sciences Bone marrow cells Cell culture techniques Cell lines Cells, Cultured Cellular immunity Cultured cells Fundamental and applied biological sciences. Psychology Hep G2 cells Hepatitis Hepatitis antigens Hepatitis B - microbiology Hepatitis B - pathology Hepatitis B Surface Antigens - immunology Hepatitis B virus Hepatitis B virus - growth & development Hepatocytes Humans Liver - pathology Lymphocytes - microbiology Lymphocytes - pathology Male Microbiology Middle Aged Replicative cycle, interference, host-virus relations, pathogenicity, miscellaneous strains Virology
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Description
Summary:	Since it has been postulated that liver hepatocytes may become infected by hepatitis B virus (HBV) in vivo through direct contact with infected macrophages, the possibility that a circulating cell of hematopoietic origin might be susceptible to infection with HBV was investigated. Cells positive for HBV surface antigen were identified in aspirates of bone marrow cells from people infected with HBV. These cells were used to prepare a lymphoblastoid suspension culture that contains HBV-infected cells.
ISSN:	0036-8075 1095-9203