Presence of non-selective type of endothelin receptor on vascular endothelium and its linkage to vasodilation

We studied the role of non-selective type (ET 14) of endothelin (ET) receptor in the vasculature, using a ligand specific to the ET 14 receptor, [Glu 9]-sarafotoxin S6b ([Glu 9]SRTb). Endothelium-containing rat thoracic aorta possessed specific binding sites for 125I-[Glu 9]SRTb, which were almost e...

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Bibliographic Details
Published in:FEBS letters 1991-04, Vol.282 (1), p.103-106
Main Authors: Takayanagi, Ryoichi, Kitazumi, Kazuhiro, Takasaki, Chikahisa, Ohnaka, Keizo, Aimoto, Saburo, Tasaka, Kenjí, Ohashi, Masao, Nawata, Hajime
Format: Article
Language:English
Subjects:
Animals
Aorta - drug effects
Aorta - physiology
Binding Sites
Binding, Competitive
Biological and medical sciences
Cell receptors
Cell structures and functions
Endothelial cell
Endothelin
Endothelins - metabolism
Endothelium
Endothelium, Vascular - drug effects
Endothelium, Vascular - metabolism
Endothelium, Vascular - physiology
Fundamental and applied biological sciences. Psychology
Molecular and cellular biology
Neuropeptide receptors
Rats
Receptor
Receptors, Cell Surface - metabolism
Receptors, Cell Surface - physiology
Receptors, Endothelin
Sarafotoxin
Swine
Vasoconstrictor Agents
Vasodilation
Vasodilation - physiology
Viper Venoms
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Summary:We studied the role of non-selective type (ET 14) of endothelin (ET) receptor in the vasculature, using a ligand specific to the ET 14 receptor, [Glu 9]-sarafotoxin S6b ([Glu 9]SRTb). Endothelium-containing rat thoracic aorta possessed specific binding sites for 125I-[Glu 9]SRTb, which were almost eliminated by removal of the endothelium, while ET-3-specific binding sites were not detected in the endothelium-intact rat aorta. Only ET 14 receptor was detected in the membranes from the endothelium of porcine thoracic aorta. [Glu 9]SRTb exerted only vasodilation in rat aortic ring. These findings indicate that ET 14 receptors are located on vascular endothelium and linked to vasodilation.
ISSN:0014-5793
1873-3468
DOI:10.1016/0014-5793(91)80454-B