L-687, 781, A NEW MEMBER OF THE PAPULACANDIN FAMILY OF β-1, 3-D-GLUCAN SYNTHESIS INHIBITORS: I. FERMENTATION, ISOLATION, AND BIOLOGICAL ACTIVITY

A new β-1, 3-D-glucan synthesis inhibitor, L-687, 781 is produced by the cultivation of Dictyochaeta simplex ATCC 20960. L-687, 781 exhibits potent in vitro antifungal activity as well as anti-Pneumocystis activity in a rat model.

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Bibliographic Details
Published in:Journal of antibiotics 1991/01/25, Vol.44(1), pp.45-51
Main Authors: VANMIDDLESWORTH, FRANK, OMSTEAD, MARY NALLIN, SCHMATZ, DENNIS, BARTIZAL, KEN, FROMTLING, ROBERT, BILLS, GERALD, NOLLSTADT, KARL, HONEYCUTT, SUSAN, ZWEERINK, MARCIA, GARRITY, GEORGE, WILSON, KEN
Format: Article
Language:English
Subjects:
Animals
Antibiotics. Antiinfectious agents. Antiparasitic agents
Antifungal agents
Antifungal Agents - isolation & purification
Antifungal Agents - pharmacology
Antifungal Agents - therapeutic use
beta-Glucans
Biological and medical sciences
Candida - drug effects
Candidiasis - drug therapy
Cryptococcus neoformans - drug effects
Disease Models, Animal
Fermentation
Fungi - drug effects
Glucans - antagonists & inhibitors
Glucans - biosynthesis
Male
Medical sciences
Mice
Mitosporic Fungi - classification
Mitosporic Fungi - metabolism
Pharmacology. Drug treatments
Pneumocystis carinii
Pneumonia, Pneumocystis - drug therapy
Pyrans - isolation & purification
Pyrans - pharmacology
Pyrans - therapeutic use
Rats
Rats, Inbred Strains
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Description
Summary:A new β-1, 3-D-glucan synthesis inhibitor, L-687, 781 is produced by the cultivation of Dictyochaeta simplex ATCC 20960. L-687, 781 exhibits potent in vitro antifungal activity as well as anti-Pneumocystis activity in a rat model.
ISSN:0021-8820
1881-1469
DOI:10.7164/antibiotics.44.45