Cofactors in Male-Female Sexual Transmission of Human Immunodeficiency Virus Type 1

In a study of human immunodeficiency virus type 1 (HIV-1)-uninfected African prostitutes, 83 (67%) of 124 sero converted to HIV-1. Oral contraceptive use (odds ratio [OR], 3.1; 95% confidence interval (CI], 1.1–8.6;P < .03), genital ulcers (mean annual episodes, 1.32 ± 0.55 in seroconverting wome...

Full description

Saved in:
Bibliographic Details
Published in:The Journal of infectious diseases 1991-02, Vol.163 (2), p.233-239
Main Authors: Plummer, Francis A., Simonsen, J. Neil, Cameron, D. William, Ndinya-Achola, Jackoniah O., Kreiss, Joan K., Gakinya, Michael N., Waiyaki, Peter, Cheang, Mary, Piot, Peter, Ronald, Allan R., Ngugi, Elizabeth N.
Format: Article
Language:English
Subjects:
Adult
AIDS/HIV
Biological and medical sciences
Chlamydia Infections - complications
Chlamydia trachomatis
Cohort Studies
Condoms
Contraceptive Devices, Male
Contraceptives, Oral
Female
Follow-Up Studies
Genital Diseases, Female - complications
Genitalia
HIV 1
HIV Infections - complications
HIV Infections - epidemiology
HIV Infections - transmission
Humans
Immunodeficiencies
Immunodeficiencies. Immunoglobulinopathies
Immunopathology
Incidence
Infections
Kenya - epidemiology
Major Articles
Male
Medical sciences
Oral contraceptives
Oral ulcers
Predisposing factors
Regression Analysis
Risk Factors
Sex Work
Sex workers
Sexual Behavior
Sexual Partners
Sexually transmitted diseases
Sexually Transmitted Diseases - complications
Sexually Transmitted Diseases - epidemiology
Sexually Transmitted Diseases - transmission
Tropical medicine
Ulcer - complications
Ulcers
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:In a study of human immunodeficiency virus type 1 (HIV-1)-uninfected African prostitutes, 83 (67%) of 124 sero converted to HIV-1. Oral contraceptive use (odds ratio [OR], 3.1; 95% confidence interval (CI], 1.1–8.6;P < .03), genital ulcers (mean annual episodes, 1.32 ± 0.55 in seroconverting women vs. 0.48 ± 0.21 in seronegative women; P < .02) and Chlamydia trachomatis infections (OR, 3.6;CI, 1.3–11.0; P < .02)were associated with increased risk of HIV-1 infection. Condom use reduced the risk of HIV-1 infection (OR, 0.11; CI, 0.05–0.27; P < .0001). Stepwise logistic regression analysis confirmed independent associations between HIV-l infection and oral contraceptive use, condom use, genital ulcers, and C. trachomatis. The presence of other sexually transmitted diseases may in part explain the heterosexual HIV-1 epidemic in Africa and may represent important targets for intervention to control HIV-1 infection.
ISSN:0022-1899
1537-6613
DOI:10.1093/infdis/163.2.233