High Risk of Severe Bleeding in Aged Patients With Chronic Idiopathic Thrombocytopenic Purpura

The purpose of this study was to estimate the incidence and to establish which factors were associated with an increased risk of hemorrhagic complications in an historic cohort of 117 consecutive and unselected patients with chronic idiopathic thrombocytopenic purpura (ITP). Sixty-eight patients (58...

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Bibliographic Details
Published in:Blood 1991-01, Vol.77 (1), p.31-33
Main Authors: Cortelazzo, Sergio, Finazzi, Guido, Buelli, Maurizio, Molteni, Anna, Viero, Piera, Barbui, Tiziano
Format: Article
Language:English
Subjects:
Adult
Age Factors
Aged
Aged, 80 and over
Biological and medical sciences
Female
Follow-Up Studies
Hematologic and hematopoietic diseases
Hemorrhage - etiology
Hemorrhage - therapy
Humans
Male
Medical sciences
Middle Aged
Platelet diseases and coagulopathies
Purpura, Thrombocytopenic - complications
Risk Factors
Splenectomy
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Summary:The purpose of this study was to estimate the incidence and to establish which factors were associated with an increased risk of hemorrhagic complications in an historic cohort of 117 consecutive and unselected patients with chronic idiopathic thrombocytopenic purpura (ITP). Sixty-eight patients (58%) underwent medical treatment and/or splenectomy and 33 (48% of treated) achieved a complete stable remission. At equivalent platelet count the incidence of major hemorrhagic complications was significantly higher in aged (> 60 years) than in younger (< 40 years) patients (10.4% v 0.4%/pt-y, relative risk = 28.9, P < .01). A previous hemorrhagic event was identified as another major risk factor for hemorrhage (relative risk = 27.5, P < .0005), while hypertension and underlying disorders had no influence. We conclude that age more than 60 years and a previous history of bleeding are major risk factors for severe hemorrhages in adults with ITP.
ISSN:0006-4971
1528-0020
DOI:10.1182/blood.V77.1.31.31