Augmentation of peritoneal clearance by dipyridamole

Augmentation of peritoneal clearance by dipyridamole. We performed a double blind crossover trial in which dipyridamole was administered to ten patients undergoing intermittent peritoneal dialysis at 2 liters/hour (10min infusion, 30min intraperitoneal dwell of dialysate and 20min drainage of dialys...

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Bibliographic Details
Published in:Kidney international 1982-12, Vol.22 (6), p.658-661
Main Authors: Rubin, Jack, Adair, Catherine, Barnes, Tom, Bower, John D.
Format: Article
Language:English
Subjects:
Adult
Clinical Trials as Topic
Dipyridamole - administration & dosage
Dipyridamole - therapeutic use
Double-Blind Method
Female
Glucose - metabolism
Humans
Inulin
Male
Middle Aged
Peritoneal Dialysis
Peritoneum - metabolism
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Summary:Augmentation of peritoneal clearance by dipyridamole. We performed a double blind crossover trial in which dipyridamole was administered to ten patients undergoing intermittent peritoneal dialysis at 2 liters/hour (10min infusion, 30min intraperitoneal dwell of dialysate and 20min drainage of dialysate). After the patients received the drug for 3 days at a dose of 75mg three times daily, peritoneal inulin clearance increased by 1.2ml/min (P < 0.05), and glucose absorption increased by 12.1g (P < 0.05). The mechanism of the observed drug-induced effects is unknown. Augmentation de la clearance peritoneale par le dipyridamole. Nous avons fait une étude croisée en double insu au cours de laquelle le dipyridamole a été administré à dix malades en dialyse péritonéale intermittente avec 2 litres/heure (10min de perfusion, 30min de stagnation intrapéritonéale du dialysat, et 20min de draînage du dialysat). Après que les patients aient reçu le médicament pendant trois jours à la dose de 75mg trois fois par jour, la clearance péritonéale de l'inuline s'est élevée de 1,2 ml/mn (P < 0,05) et l'absorption de glucose s'est accrue de 12,1g (P < 0,05). Le mécanisme de ces effets médicamenteux est inconnu.
ISSN:0085-2538
1523-1755
DOI:10.1038/ki.1982.226