Muscle glycolipids in inherited muscular dystrophy of chickens

Gangliosides and neutral glycolipids of muscles from normal and dystrophic chickens were studied. Total glycolipid content of the degenerating muscles was higher than the normal muscles. In addition, the myopathic muscles contained a ganglioside which was absent in the unaffected muscles from normal...

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Bibliographic Details
Published in:FEBS letters 1982-12, Vol.150 (2), p.359-364
Main Authors: Kundu, Samar K., Misra, Lalit K., Luthra, Madan G.
Format: Article
Language:English
Subjects:
Aging
Animals
As GM1
As GM2
CDH
Chicken muscular dystrophy
Chickens
CMH
CTH
Degenerating muscle
Dystrophic-specific ganglioside
Forss
Forssman glycolipid
G M2
galactosyl or glucosylceramide
ganglio-N-tetraosylceramide
ganglio-N-triaosylceramide
Ganglioside
Gangliosides - isolation & purification
Gangliosides - metabolism
globotriaosylceramide
Glycolipids - isolation & purification
Glycolipids - metabolism
GM2
lactoneotetraosylceramide Gal(β1–4)GlcNAc(β1–3)Gal-(β1–4)Glc-Cer
lactosylceramide
lactotriaosylceramide GlcNAc(β1–3)Gal(β1–4)-Glc-Cer
Muscle Development
Muscles - metabolism
Muscular Dystrophy, Animal - metabolism
Neutral glycolipid
sialosyllacto-N-nor-hexaosylceramide NeuAc(α2–3)[Gal(β1–4)GlcNAc(β1–3)]2Gal-(β1–4)Glc-Cer
sialosyllactoneotetraosylceramide NeuAc(α2–3)Gal(β1–4)GlcNAc(β1–3)-Gal(β1–4)Glc-Cer
SNH
SPG
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Description
Summary:Gangliosides and neutral glycolipids of muscles from normal and dystrophic chickens were studied. Total glycolipid content of the degenerating muscles was higher than the normal muscles. In addition, the myopathic muscles contained a ganglioside which was absent in the unaffected muscles from normal and dystrophic chickens. Based on the thin-layer chromatographic mobility, treatment with neuraminidases from Vibrio cholerae and Arthrobacter ureafaciens, and reactivity of the asialo-derivative towards anti-ganglio- N-triaosylceramide antibody, the dystrophic-specific ganglioside was tentatively identified as G M2. Data obtained from young and old dystrophic chickens suggested a direct relationship of this ganglioside to muscular dystrophy.
ISSN:0014-5793
1873-3468
DOI:10.1016/0014-5793(82)80768-0