Single-Nucleotide Polymorphisms of Vascular Endothelial Growth Factor in Psoriasis of Early Onset

Vascular endothelial growth factor (VEGF) – a stimulus of angiogenesis – is produced by epidermal keratinocytes, and elevated levels have been found in plaques of psoriasis. Polymorphisms in the VEGF gene regulate production of VEGF. We postulated that patients with psoriasis may have altered system...

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Bibliographic Details
Published in:Journal of investigative dermatology 2004-01, Vol.122 (1), p.209-215
Main Authors: Young, Helen S., Bhushan, Monica, Griffiths, Christopher E.M., Summers, Angela M., Brenchley, Paul E.C.
Format: Article
Language:English
Subjects:
Adolescent
Adult
Age of Onset
Aged
Aged, 80 and over
angiogenesis
Biological and medical sciences
Dermatology
Extracellular Matrix Proteins - blood
Female
Genotype
Humans
Male
Medical sciences
Middle Aged
Polymorphism, Single Nucleotide
Psoriasis - blood
Psoriasis - genetics
Psoriasis. Parapsoriasis. Lichen
Vascular Endothelial Growth Factor A - blood
Vascular Endothelial Growth Factor A - genetics
Vascular Endothelial Growth Factor Receptor-1
Vascular Endothelial Growth Factor Receptor-2 - blood
VEGF
VEGF receptors
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Summary:Vascular endothelial growth factor (VEGF) – a stimulus of angiogenesis – is produced by epidermal keratinocytes, and elevated levels have been found in plaques of psoriasis. Polymorphisms in the VEGF gene regulate production of VEGF. We postulated that patients with psoriasis may have altered systemic expression of VEGF consequent upon programming at the genomic level. We investigated the genetic basis of VEGF expression in patients with type 1 (onset before age 40 y) chronic plaque psoriasis compared to healthy controls and also measured plasma levels of VEGF and its receptors flt-1 and KDR. Patients with severe disease, and those with onset of psoriasis between the ages of 20 and 40 y showed significantly increased frequency of the +405 CC genotype (p=0.04 and p=0.02) and the C allele (p=0.03 and p=0.02), respectively, compared to healthy controls. Plasma levels of VEGF and flt-1 were significantly detectable in patients with psoriasis compared with controls (p
ISSN:0022-202X
1523-1747
DOI:10.1046/j.0022-202X.2003.22107.x