Electrochemical Biosensing Platforms Using Platinum Nanoparticles and Carbon Nanotubes

Platinum nanoparticles with a diameter of 2−3 nm were prepared and used in combination with single-wall carbon nanotubes (SWCNTs) for fabricating electrochemical sensors with remarkably improved sensitivity toward hydrogen peroxide. Nafion, a perfluorosulfonated polymer, was used to solubilize SWCNT...

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Bibliographic Details
Published in:Analytical chemistry (Washington) 2004-02, Vol.76 (4), p.1083-1088
Main Authors: Hrapovic, Sabahudin, Liu, Yali, Male, Keith B, Luong, John H. T
Format: Article
Language:English
Subjects:
Analytical chemistry
Aspergillus niger - enzymology
Biological and medical sciences
Biosensing Techniques - methods
Biosensors
Biotechnology
Chemistry
Electrochemical methods
Electrochemistry - methods
Electrodes
Exact sciences and technology
Fundamental and applied biological sciences. Psychology
Glucose - analysis
Glucose Oxidase - chemistry
Hydrogen Peroxide - analysis
Methods. Procedures. Technologies
Nanoparticles
Nanotechnology - methods
Nanotubes
Nanotubes, Carbon - chemistry
Platinum
Platinum - chemistry
Polymers
Scientific imaging
Various methods and equipments
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Summary:Platinum nanoparticles with a diameter of 2−3 nm were prepared and used in combination with single-wall carbon nanotubes (SWCNTs) for fabricating electrochemical sensors with remarkably improved sensitivity toward hydrogen peroxide. Nafion, a perfluorosulfonated polymer, was used to solubilize SWCNTs and also displayed strong interactions with Pt nanoparticles to form a network that connected Pt nanoparticles to the electrode surface. TEM and AFM micrographs illustrated the deposition of Pt nanoparticles on carbon nanotubes whereas cyclic voltammetry confirmed an electrical contact through SWCNTs between Pt nanoparticles and the glassy carbon (GC) or carbon fiber backing. With glucose oxidase (GOx) as an enzyme model, we constructed a GC or carbon fiber microelectrode-based biosensor that responds even more sensitively to glucose than the GC/GOx electrode modified by Pt nanoparticles or CNTs alone. The response time and detection limit (S/N = 3) of this biosensor was determined to be 3 s and 0.5 μM, respectively.
ISSN:0003-2700
1520-6882
DOI:10.1021/ac035143t