Quantitative Trait Loci for Health Traits in Finnish Ayrshire Cattle

A whole-genome scan was conducted to search for quantitative trait loci (QTL) affecting health traits in Finnish Ayrshire dairy cattle. The mapping population consisted of 12 bulls and their 491 sons in a granddaughter design. A total of 150 markers were typed covering all 29 autosomes. The traits u...

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Bibliographic Details
Published in:Journal of dairy science 2004-02, Vol.87 (2), p.443-449
Main Authors: Schulman, N.F., Viitala, S.M., de Koning, D.J., Virta, J., Mäki-Tanila, A., Vilkki, J.H.
Format: Article
Language:English
Subjects:
alleles
animal health
Animal productions
Animals
Ayrshire (cattle breed)
Biological and medical sciences
bovine mastitis
Cattle - genetics
Cell Count
Chromosome Mapping
dairy bulls
dairy cow
Female
Food industries
Fundamental and applied biological sciences. Psychology
genetic markers
health
Health Status
Male
mastitis
Mastitis, Bovine - genetics
Milk - cytology
Milk and cheese industries. Ice creams
QTL
Quantitative Trait Loci - genetics
Regression Analysis
somatic cell count
Terrestrial animal productions
Vertebrates
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Summary:A whole-genome scan was conducted to search for quantitative trait loci (QTL) affecting health traits in Finnish Ayrshire dairy cattle. The mapping population consisted of 12 bulls and their 491 sons in a granddaughter design. A total of 150 markers were typed covering all 29 autosomes. The traits under study were somatic cell score, mastitis, and a group of other veterinary treatments. Effects of the QTL and positions were estimated with the regression method. When carrying out interval mapping on each chromosome, cofactors were used to adjust for QTL identified at other chromosomes. Empirical P-values were obtained by permutation. Altogether 17 QTL were detected with genomewise significant P-values in the across family analysis. Quantitative trait loci affecting SCS were identified on chromosomes 1, 3, 11, 18, 21, 24, 27, 29, and QTL for mastitis on chromosomes 14, 18. Quantitative trait loci for other veterinary treatments were found on chromosomes 1, 2, 5, 8, 15, 22, and 23. The allele substitution effects were from 0.5 to 1.7 genetic standard deviations. The positions of these health QTL did not overlap with milk QTL detected in previous studies of the same population.
ISSN:0022-0302
1525-3198
DOI:10.3168/jds.S0022-0302(04)73183-5