Primary osteosarcoma of the lung. Report of two cases and review of the literature

Two cases of primary osteosarcoma of the lung are presented. In one case, the radiologic, clinical, and cytologic findings led to a preoperative diagnosis of undifferentiated carcinoma of the lung. In the second case, a lung nodule was discovered during postchemotherapy follow-up in a patient with l...

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Bibliographic Details
Published in:The Journal of thoracic and cardiovascular surgery 1990-12, Vol.100 (6), p.867-873
Main Authors: Loose, JH, el-Naggar, AK, Ro, JY, Huang, WL, McMurtrey, MJ, Ayala, AG
Format: Article
Language:English
Subjects:
Biological and medical sciences
Female
Humans
Lung Neoplasms - diagnostic imaging
Lung Neoplasms - pathology
Male
Medical sciences
Middle Aged
Osteosarcoma - diagnostic imaging
Osteosarcoma - pathology
Osteosarcoma - secondary
Pneumology
Radiography
Tumors of the respiratory system and mediastinum
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Summary:Two cases of primary osteosarcoma of the lung are presented. In one case, the radiologic, clinical, and cytologic findings led to a preoperative diagnosis of undifferentiated carcinoma of the lung. In the second case, a lung nodule was discovered during postchemotherapy follow-up in a patient with lymphoma. Fine needle aspiration in the second case showed lymphoma, and further chemotherapy was instituted; however, persistent growth of the nodule prompted a resection. Microscopic examination of the resected tumors in both cases revealed histologic features of high-grade osteosarcoma. Flow cytometric analyses of the primary tumors showed abnormal hyperdiploid deoxyribonucleic acid populations in accordance with those seen in high-grade malignant neoplasms. Immunohistochemical studies supported a mesenchymal origin for these tumors. These tumors shared clinical features with other reported cases of primary osteosarcoma of the lung such as large size at diagnosis, occurrence in older individuals, and aggressive behavior.
ISSN:0022-5223
1097-685X
DOI:10.1016/s0022-5223(19)36829-1