Polymorphisms in cytokines and growth factor genes and their association with acute rejection and recurrence of hepatitis C virus disease in liver transplantation

Acute rejection (AR) and recurrence of hepatitis C virus (HCV) infection are complications after liver transplantation (LTx). Genetic factors play a role in cytokine production as a consequence of polymorphisms within cytokine genes. Our goal was to identify genetic factors that might be associated...

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Bibliographic Details
Published in:Clinical genetics 2004-03, Vol.65 (3), p.191-201
Main Authors: Mas, VR, Fisher, RA, Maluf, DG, Archer, KJ, Contos, MJ, Mills, SA, Shiffman, ML, Wilkinson, DS, Oliveros, L, Garrett, CT, Ferreira-Gonzalez, A
Format: Article
Language:English
Subjects:
Adult
Biological and medical sciences
cytokines
Cytokines - genetics
Female
General aspects. Genetic counseling
genetic polymorphisms
Genotype
Graft Rejection - etiology
Graft Rejection - genetics
Growth Substances - genetics
Hepatitis C - etiology
Hepatitis C - genetics
hepatitis C virus
Humans
Interleukin-10 - genetics
Interleukin-6 - genetics
liver transplantation
Liver Transplantation - adverse effects
Male
Medical genetics
Medical sciences
Middle Aged
Polymorphism, Single Nucleotide
Recurrence
single-nucleotide polymorphisms
Tumor Necrosis Factor-alpha - genetics
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Summary:Acute rejection (AR) and recurrence of hepatitis C virus (HCV) infection are complications after liver transplantation (LTx). Genetic factors play a role in cytokine production as a consequence of polymorphisms within cytokine genes. Our goal was to identify genetic factors that might be associated with AR and recurrence of HCV in liver transplant recipients (LTxRs). We studied 77 Caucasian LTxRs and 100 Caucasian healthy individuals. We studied single‐nucleotide polymorphisms (SNPs) in tumor necrosis factor‐α[TNF‐α, interleukin‐6 (IL‐6), IL‐10, transforming growth factor‐β1, and angiotensin‐converting enzyme genes by SNaPSHOT™ Multiplex assay. SNPs were classified as high producers (HP), intermediate producers (IP), or low producers (LP), and their association with AR and recurrence of HCV were studied. The frequency of TNF‐α IP and HP genotypes was significantly higher in LTxRs with AR in comparison to patients without AR (TNF‐α HP −238: 63 vs 20%, p 
ISSN:0009-9163
1399-0004
DOI:10.1111/j.0009-9163.2004.00208.x