Apolipoprotein B-100 XbaI gene polymorphism in gallbladder cancer

Genetic polymorphisms in the apolipoprotein B (apoB) gene have been reported to be associated with altered serum lipids and susceptibility to cholesterol gallstones (GS). Gallstones are among the well-known risk factors for carcinoma of the gallbladder (GBC). In the present study, the association be...

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Bibliographic Details
Published in:Human genetics 2004-02, Vol.114 (3), p.280-283
Main Authors: Singh, Mahendra Kumar, Pandey, Udai Bhan, Ghoshal, Uday Chand, Srivenu, Itha, Kapoor, Vinay Kumar, Choudhuri, Gourdas, Mittal, Balraj
Format: Article
Language:English
Subjects:
Adult
Aged
Alleles
Apolipoprotein B-100
Apolipoproteins
Apolipoproteins B - genetics
Base Sequence
Blood lipids
Cancer
Cholelithiasis - complications
Cholesterol
Deoxyribonucleases, Type II Site-Specific - genetics
Disease susceptibility
Female
Gallbladder cancer
Gallbladder Neoplasms - complications
Gallbladder Neoplasms - genetics
Gallstones
Gene Frequency
Genes
Genetic aspects
Genetic polymorphisms
Genetic Predisposition to Disease
Genetic research
Homozygote
Humans
Male
Odds Ratio
Polymerase Chain Reaction
Polymorphism, Genetic
Risk Factors
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Summary:Genetic polymorphisms in the apolipoprotein B (apoB) gene have been reported to be associated with altered serum lipids and susceptibility to cholesterol gallstones (GS). Gallstones are among the well-known risk factors for carcinoma of the gallbladder (GBC). In the present study, the association between the XbaI polymorphism of the apo B gene was examined in patients with GBC and GS and in normal controls in a north Indian population. DNA samples from patients with GBC (n=153), GS (n=117) and healthy subjects (n=137) were analysed for the apoB- XbaI polymorphism by polymerase chain reaction followed by restriction fragment length polymorphism. The genotype X+/- was less frequent in patients with GBC (39.2%) than in those with GS (68.3%) and in normal subjects (66.4%; P
ISSN:0340-6717
1432-1203
DOI:10.1007/s00439-003-1056-8