Quantitative EEG and perfusional single photon emission computed tomography correlation during long-term donepezil therapy in Alzheimer's disease

Objective: There is an increasing interest in the effects of the acetylcholinesterase inhibitors (AChEIs) in Alzheimer's disease (AD), as investigated by means of objective, neurophysiological tools. In an open-label study, we evaluated the neurophysiological effects of chronic administration o...

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Bibliographic Details
Published in:Clinical neurophysiology 2004, Vol.115 (1), p.39-49
Main Authors: Rodriguez, Guido, Vitali, Paolo, Canfora, Michela, Calvini, Piero, Girtler, Nicola, De Leo, Caterina, Piccardo, Arnoldo, Nobili, Flavio
Format: Article
Language:English
Subjects:
Acetylcholinesterase inhibitor
Aged
Aged, 80 and over
Alzheimer Disease - diagnostic imaging
Alzheimer Disease - drug therapy
Alzheimer Disease - physiopathology
Alzheimer's disease
Biological and medical sciences
Brain single photon emission computed tomography
Cerebrovascular Circulation - physiology
Donepezil
Electrodiagnosis. Electric activity recording
Electroencephalography
Female
Humans
Indans - therapeutic use
Investigative techniques, diagnostic techniques (general aspects)
Male
Medical sciences
Middle Aged
Nervous system
Nootropic Agents - therapeutic use
Piperidines - therapeutic use
Quantitative EEG
Radiopharmaceuticals
Statistical parametric mapping
Technetium Tc 99m Exametazime
Tomography, Emission-Computed, Single-Photon
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Summary:Objective: There is an increasing interest in the effects of the acetylcholinesterase inhibitors (AChEIs) in Alzheimer's disease (AD), as investigated by means of objective, neurophysiological tools. In an open-label study, we evaluated the neurophysiological effects of chronic administration of donepezil to AD patients, by means of a correlative approach between quantitative EEG (qEEG) and perfusional brain single photon emission computed tomography (SPECT). Methods: Sixteen patients (mean age: 74.8±7.9 years) with mild to moderate AD (MMSE score >13, mean: 20.7±4.6) underwent qEEG and SPECT examinations at the time of diagnosis ( t 0) and after approximately 1 year of donepezil therapy ( t 1). The brain SPECT ( 99mTc-hexamethylpropyleneamine oxime) was performed by means of a high-resolution SPECT camera; the qEEG was recorded from 19 scalp electrodes by average reference and digitized at 512 Hz. The mean frequency (MF) value of the mean power spectrum (fast Fourier transform) from 4 brain regions (one frontal and one temporal-parietal in each hemisphere) was chosen for statistical analysis. Changes in MMSE score and qEEG-MF values between t 0 and t 1 were assessed by analysis of variance. SPECT differences between t 0 and t 1, as well as the relationships between SPECT and qEEG changes, were assessed by statistical parametric mapping (SPM 99; height threshold: P=0.001 at cluster level). Results: Between t 0 and t 1, the MMSE score significantly ( P
ISSN:1388-2457
1872-8952
DOI:10.1016/S1388-2457(03)00321-3