Prebiotic Inulin Enriched with Oligofructose in Combination with the Probiotics Lactobacillus rhamnosus and Bifidobacterium lactis Modulates Intestinal Immune Functions in Rats

Probiotics (PRO) modulate systemic immunity in animals and humans. In contrast, the effects of prebiotics (PRE) on systemic and intestinal immunity have not been investigated. Whether the combined application of PRO and PRE [synbiotics (SYN)] has synergistic or additive effects is presently unknown....

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Bibliographic Details
Published in:The Journal of nutrition 2004-01, Vol.134 (1), p.153-156
Main Authors: Roller, Monika, Rechkemmer, Gerhard, Watzl, Bernhard
Format: Article
Language:English
Subjects:
animal models
Animals
Bifidobacterium
Bifidobacterium animalis
Biological and medical sciences
CD4-Positive T-Lymphocytes - immunology
CD8-Positive T-Lymphocytes - immunology
cytokines
Diet
Feeding. Feeding behavior
fructose
Fundamental and applied biological sciences. Psychology
gut
high fat diet
immune response
immune system
Immune sytem
immunoglobulin A
Immunoglobulin A, Secretory - analysis
immunostimulants
Interleukin-10 - biosynthesis
intestines
Intestines - immunology
inulin
Inulin - administration & dosage
Killer Cells, Natural - immunology
Lactobacillus
Lactobacillus rhamnosus
lymph nodes
Male
Monocytes - immunology
neutrophils
Neutrophils - immunology
oligosaccharides
Oligosaccharides - administration & dosage
Peyer's patches
Peyer's Patches - immunology
Phagocytosis
prebiotic
prebiotics
probiotic
probiotics
Probiotics - administration & dosage
rat
Rats
Rats, Inbred F344
Respiratory Burst
spleen
synbiotic
synbiotics
Vertebrates: anatomy and physiology, studies on body, several organs or systems
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Summary:Probiotics (PRO) modulate systemic immunity in animals and humans. In contrast, the effects of prebiotics (PRE) on systemic and intestinal immunity have not been investigated. Whether the combined application of PRO and PRE [synbiotics (SYN)] has synergistic or additive effects is presently unknown. Therefore, PRO (Lactobacillus rhamnosus GG and Bifidobacterium lactis Bb12), PRE (inulin enriched with oligofructose), and SYN (combination of PRO and PRE) were fed to F344 rats for 4 wk as supplements to a high fat diet. Functions of immune cells isolated from peripheral blood mononuclear cells (PBMC), spleen, mesenterial lymph nodes and Peyer's patches (PP) were investigated. The SYN supplement increased secretory immunoglobulin A (sIgA) production in the ileum compared with controls fed the high fat diet alone (P < 0.05), and decreased the oxidative burst activity of blood neutrophils (P < 0.05) compared with rats fed PRO. The PRE supplement enhanced the production of interleukin-10 (P < 0.05) in PP as well as the production of sIgA in the cecum (P < 0.05), compared with controls. The PRO supplement modestly affected immune functions, whereas systemic immunomodulatory effects were observed in rats fed SYN. The PRE supplement primarily acted at the level of the gut-associated lymphoid tissue. The combined application of PRO and PRE has different effects from those of the individual supplements, but does not simply result in additive or synergistic effects.
ISSN:0022-3166
1541-6100
DOI:10.1093/jn/134.1.153