Long term consequences of the 1944–1945 Dutch famine on the insulin‐like growth factor axis

The insulin‐like growth factor axis is highly responsive to nutritional status and may be involved as one of the underlying mechanisms through which caloric restriction could affect cancer risk. High levels of circulating insulin‐like growth factor (IGF)‐I, or IGF‐I relative to IGF binding protein (...

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Bibliographic Details
Published in:International journal of cancer 2004-02, Vol.108 (4), p.628-630
Main Authors: Elias, Sjoerd G., Keinan‐Boker, Lital, Peeters, Petra H.M., Van Gils, Carla H., Kaaks, Rudolf, Grobbee, Diederick E., Van Noord, Paulus A.H.
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Biological and medical sciences
Body Mass Index
C-Peptide - metabolism
Caloric Restriction
Child
Child, Preschool
Cohort Studies
Female
Gynecology. Andrology. Obstetrics
Humans
IGFBP
IGF‐I
Insulin-Like Growth Factor Binding Protein 1 - blood
Insulin-Like Growth Factor Binding Protein 2 - blood
Insulin-Like Growth Factor Binding Protein 3 - blood
Insulin-Like Growth Factor I - metabolism
Mammary gland diseases
Medical sciences
Middle Aged
Netherlands
Postmenopause
Risk Factors
Starvation - blood
Time Factors
Tumors
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Summary:The insulin‐like growth factor axis is highly responsive to nutritional status and may be involved as one of the underlying mechanisms through which caloric restriction could affect cancer risk. High levels of circulating insulin‐like growth factor (IGF)‐I, or IGF‐I relative to IGF binding protein (IGFBP)‐3 have been related to various human cancer types. In a group of 87 postmenopausal women, we found that childhood exposure to the 1944–1945 Dutch famine was associated with increased plasma levels of IGF‐I and IGFBP‐3, whereas IGFBP‐1 and ‐2 levels were weakly decreased. These results are opposite to immediate responses seen under starvation and we hypothesize that this could indicate a permanent overshoot upon improvement of nutritional status after the famine. © 2003 Wiley‐Liss, Inc.
ISSN:0020-7136
1097-0215
DOI:10.1002/ijc.11584