Cerebral hemodynamics in young hypertensive subjects and effects of atenolol treatment

The aim of this study was to evaluate changes in cerebral hemodynamics in young patients with uncomplicated hypertension before and after effective antihypertensive treatment with a beta-blocker drug. Changes in mean flow velocity in the middle cerebral artery from normal condition to hypercapnia we...

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Bibliographic Details
Published in:Journal of the neurological sciences 1998-07, Vol.159 (1), p.115-119
Main Authors: Troisi, Elio, Attanasio, Antonio, Matteis, Maria, Bragoni, Maura, Monaldo, Bruno C, Caltagirone, Carlo, Silvestrini, Mauro
Format: Article
Language:English
Subjects:
Adult
Antihypertensive agents
Antihypertensive Agents - therapeutic use
Antihypertensive therapy
Atenolol - therapeutic use
Biological and medical sciences
Blood Flow Velocity
Carbon Dioxide - blood
Cardiovascular system
Cerebral Arteries - diagnostic imaging
Cerebral Arteries - physiology
Cerebral Arteries - physiopathology
Cerebral blood flow
Cerebrovascular Circulation - drug effects
Cerebrovascular reactivity
Female
Hemodynamics - drug effects
Humans
Hypertension
Hypertension - drug therapy
Hypertension - physiopathology
Male
Medical sciences
Pharmacology. Drug treatments
Reference Values
Transcranial Doppler ultrasonography
Ultrasonography, Doppler, Transcranial
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Summary:The aim of this study was to evaluate changes in cerebral hemodynamics in young patients with uncomplicated hypertension before and after effective antihypertensive treatment with a beta-blocker drug. Changes in mean flow velocity in the middle cerebral artery from normal condition to hypercapnia were evaluated by means of a transcranial Doppler in 42 hypertensive patients and 21 healthy subjects comparable for age and sex distribution. We obtained hypercapnia with breath-holding and evaluated cerebrovascular reactivity with the breath-holding index (BHI). After a baseline evaluation (time 0), patients were randomly assigned to a placebo (group 1) or atenolol (group 2) therapy. The evaluation was repeated after 30 (time 1) and 60 (time 2) days of treatment. Before treatment, hypertensive patients had significantly lower BHI values (0.96±0.1 group 1 and 0.85±0.3 group 2) than controls (1.69±0.4) ( P
ISSN:0022-510X
1878-5883
DOI:10.1016/S0022-510X(98)00147-6