COCHLIOQUINONE A, A NEMATOCIDAL AGENT WHICH COMPETES FOR SPECIFIC [3H]IVERMECTIN BINDING SITES

Cochlioquinone A, isolated from the fungus Helminthosporium sativum, was found to have nematocidal activity. Cochlioquinone A is a competitive inhibitor of specific [3H]ivermectin binding suggesting that cochlioquinone A and ivermectin interact with the same membrane receptor.

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Bibliographic Details
Published in:Journal of antibiotics 1990/09/25, Vol.43(9), pp.1179-1182
Main Authors: SCHAEFFER, JAMES M., FRAZIER, EASTER G., BERGSTROM, ALAN R., WILLIAMSON, JOANNE M., LIESCH, JERROLD M., GOETZ, MICHAEL A.
Format: Article
Language:English
Subjects:
Animals
Antibiotics. Antiinfectious agents. Antiparasitic agents
Antinematodal Agents - metabolism
Antinematodal Agents - pharmacology
Antiparasitic agents
Benzoquinones - metabolism
Benzoquinones - pharmacology
Binding Sites
Binding, Competitive
Biological and medical sciences
Caenorhabditis - drug effects
Ivermectin - metabolism
Medical sciences
Molecular Structure
Pharmacology. Drug treatments
Receptors, Drug - metabolism
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Description
Summary:Cochlioquinone A, isolated from the fungus Helminthosporium sativum, was found to have nematocidal activity. Cochlioquinone A is a competitive inhibitor of specific [3H]ivermectin binding suggesting that cochlioquinone A and ivermectin interact with the same membrane receptor.
ISSN:0021-8820
1881-1469
DOI:10.7164/antibiotics.43.1179