Differentiation of bronchogenic carcinoma from secondary changes, obstructive pneumonitis and/or collapse by I-123 IMP lung imaging

Serial lung images with N-isopropyl-p-[I-123]-iodoamphetamine (I-123 IMP) were obtained to assess the imaging findings and to clarify the lesion to uptake relationships in 74 lesions in 73 patients with various histological types of bronchogenic carcinoma. A decreased uptake area was observed in all...

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Bibliographic Details
Published in:Annals of nuclear medicine 1990-04, Vol.4 (1), p.1-13
Main Authors: Nakajo, M, Uchiyama, N, Shimada, J, Shinohara, S, Iriki, A, Hirotsu, Y, Egawa, K, Fukunaga, H, Norimatsu, Y
Format: Article
Language:English
Subjects:
Adenocarcinoma - diagnostic imaging
Adenocarcinoma, Bronchiolo-Alveolar - diagnostic imaging
Adult
Aged
Aged, 80 and over
Amphetamines
Carcinoma, Bronchogenic - diagnostic imaging
Carcinoma, Non-Small-Cell Lung - diagnostic imaging
Carcinoma, Small Cell - diagnostic imaging
Carcinoma, Squamous Cell - diagnostic imaging
Female
Humans
Iodine Radioisotopes
Iofetamine
Lung Neoplasms - diagnostic imaging
Male
Middle Aged
Pneumonia - diagnostic imaging
Pulmonary Atelectasis - diagnostic imaging
Radionuclide Imaging
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Summary:Serial lung images with N-isopropyl-p-[I-123]-iodoamphetamine (I-123 IMP) were obtained to assess the imaging findings and to clarify the lesion to uptake relationships in 74 lesions in 73 patients with various histological types of bronchogenic carcinoma. A decreased uptake area was observed in all 74 lesions in the initial one or two-min I-123 IMP image. The initial image was analogous to a Tc-99m MAA lung perfusion image in 70 patients in whom both lung imaging procedures were performed. The imaging findings changed following this initial phase. At 4 hr, the lesion was depicted as either areas of decreased uptake or increased uptake or a combination of the two. Comparison between the lesion findings in the 4-hr I-123 IMP images, radiograms and removed specimens revealed that areas of decreased uptake corresponded to the cancerous portions of the lung mass or pleural effusion and areas of increased uptake corresponded to inflammatory portions including obstructive pneumonitis and/or collapse. Thus, the 4-hr I-123 IMP lung images can be used to discriminate the cancerous portion from associated secondary changes, obstructive pneumonitis and/or collapse.
ISSN:0914-7187
1864-6433
DOI:10.1007/BF03165653