Highly Complex Chromosomal Rearrangement of Chromosome 9 in a Case of Chronic Myeloid Leukemia

A 63-year-old man with chronic myeloid leukemia (CML) was found to have a new complex Philadelphia translocation. All of the bone marrow cells had a rearrangement of a five-way translocation, t(9;22;10;12;1), involving a single chromosome 9. The patient went into blast crisis two years after initial...

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Bibliographic Details
Published in:Cancer genetics and cytogenetics 1998-07, Vol.104 (2), p.153-156
Main Authors: Lau, Lai-Ching, Knight, Louise, Tien, Sim-Leng, Lim, Ping, Yong, Min-Hwee, Chong, Yap-Yee
Format: Article
Language:English
Subjects:
Biological and medical sciences
Chromosomes, Human, Pair 1
Chromosomes, Human, Pair 10
Chromosomes, Human, Pair 12
Chromosomes, Human, Pair 22
Chromosomes, Human, Pair 9
Hematologic and hematopoietic diseases
Humans
In Situ Hybridization, Fluorescence
Karyotyping
Leukemia, Myelogenous, Chronic, BCR-ABL Positive - genetics
Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis
Male
Medical sciences
Middle Aged
Translocation, Genetic
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Summary:A 63-year-old man with chronic myeloid leukemia (CML) was found to have a new complex Philadelphia translocation. All of the bone marrow cells had a rearrangement of a five-way translocation, t(9;22;10;12;1), involving a single chromosome 9. The patient went into blast crisis two years after initial diagnosis and the karyotype remained unchanged. He died in blast crisis 10 months later. We believe this case is a unique 5-way translocation in which four chromosomes were translocated to a single chromosome.
ISSN:0165-4608
1873-4456
DOI:10.1016/S0165-4608(97)00451-2