Sexual and Non-Sexual Intrafamilial Spread of Hepatitis C Virus: Intrafamilial Transmission of HCV

The rate of intrafamilial transmission of the hepatitis C virus (HCV) was investigated in 90 family members of 41 index patients with type C chronic liver disease. Antibody to HCV (anti-HCV) was detected by the EIA method (Abbott-Axsym Sys) and Hepatitis C virus RNA, by the polymerase chain reaction...

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Bibliographic Details
Published in:European journal of epidemiology 1998-04, Vol.14 (3), p.225-228
Main Authors: Saltoğlu, N., Taşova, Y., Burgut, R., Dündar, İ. H.
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Antibodies, Viral - blood
Biological and medical sciences
Biopsy
Blood & organ donations
Case-Control Studies
Chi-Square Distribution
Child
Child, Preschool
Children
Disease Transmission, Infectious - statistics & numerical data
Families & family life
Family Health
Family members
Female
Health Surveys
Hepacivirus
Hepacivirus - isolation & purification
Hepatitis
Hepatitis C
Hepatitis C - transmission
Hepatitis C - virology
Hepatitis C virus
Human viral diseases
Humans
Infections
Infectious Disease Transmission, Vertical - statistics & numerical data
Infectious diseases
Intrafamilial transmission
Liver cirrhosis
Liver diseases
Male
Medical sciences
Middle Aged
Nuclear Family
Polymerase Chain Reaction
Predisposing factors
RNA
Sexual transmission
Sexually Transmitted Diseases - classification
Spouses
Surgery
Turkey - epidemiology
Viral diseases
Viral hepatitis
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Summary:The rate of intrafamilial transmission of the hepatitis C virus (HCV) was investigated in 90 family members of 41 index patients with type C chronic liver disease. Antibody to HCV (anti-HCV) was detected by the EIA method (Abbott-Axsym Sys) and Hepatitis C virus RNA, by the polymerase chain reaction (Nested PCR). We also investigated the presence of anti-HCV in 350 healthy persons (control group). The subjects in the study included 38 spouses, 45 children and others (1 relative and 6 parents). Four family members including 3/38 (7.8%) spouses and 1 sister were found to be positive for anti HCV antibodies but none had HCV RNA. Anti-HCV was not detected in the children of index patients. The prevalence of anti-HCV in the families of index patients was significantly higher than in the controls (4.3% versus 0.85%) (p = 0.0355). We concluded that the intrafamilial transmission of HCV is possible but occurs at a low rate.
ISSN:0393-2990
1573-7284
DOI:10.1023/A:1007455509185