The effect of hexadecylphosphocholine on the degradation of mitochondrial phospholipids

Hexadecylphosphocholine (HePC) is known as antitumor agent but the mechanism has not yet been understood. In rat liver mitochondria its effect on phospholipid transformation has been studied by quantitative HPTLC and phosphorus determination. From the results it can be concluded that HePC influences...

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Bibliographic Details
Published in:Molecular and cellular biochemistry 1998-06, Vol.183 (1-2), p.169-173
Main Authors: Vagina, O, Gellerich, F N, Ulbrich-Hofmann, R
Format: Article
Language:English
Subjects:
Animals
Calcium
Calcium - pharmacology
Chromatography, Thin Layer - methods
Dose-Response Relationship, Drug
Mitochondria, Liver - chemistry
Mitochondria, Liver - drug effects
Mitochondria, Liver - metabolism
Phospholipids - metabolism
Phosphorylcholine - analogs & derivatives
Phosphorylcholine - pharmacology
Rats
Time Factors
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Summary:Hexadecylphosphocholine (HePC) is known as antitumor agent but the mechanism has not yet been understood. In rat liver mitochondria its effect on phospholipid transformation has been studied by quantitative HPTLC and phosphorus determination. From the results it can be concluded that HePC influences the activities of phospholipase A2, phospholipase C, phospholipase D, and lysophospholipase A. The phospholipid transformation as well as the influence of HePC are affected by exogenous calcium ions. In the presence of calcium HePC has been found to inhibit enzyme activities, whereas in the absence of exogenous calcium ions enzymatic phospholipid transformations are activated or inhibited depending on HePC concentrations.
ISSN:0300-8177
1573-4919
DOI:10.1023/A:1006826122602