The epidermal growth factor receptor pathway in relation to pelvic lymph node metastasis and survival in early-stage cervical cancer

Summary The objective of this study is to correlate the expression of epidermal growth factor receptor (EGFR) components with clinical behavior of early-stage cervical cancer. Tissue samples of 336 consecutive Federation of International Gynecologists and Obstetricians stage IB-IIA cervical cancer p...

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Published in:Human pathology 2010-12, Vol.41 (12), p.1735-1741
Main Authors: Eijsink, Jasper J.H., MD, Noordhuis, Maartje G, ten Hoor, Klaske A, Kok, Mirjam, Hollema, Harry, MD, PhD, de Bock, Geertruida H., PhD, Nijman, Hans W., MD, PhD, Schuuring, Ed, PhD, Wisman, G. Bea A., PhD, van der Zee, Ate G.J., MD, PhD
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Aged, 80 and over
Biological and medical sciences
Biomarkers, Tumor - metabolism
Cancer therapies
Carcinoma, Squamous Cell - metabolism
Carcinoma, Squamous Cell - mortality
Carcinoma, Squamous Cell - secondary
Cervical cancer
Cervix Uteri - metabolism
Cervix Uteri - pathology
Cervix Uteri - surgery
Chemotherapy
EGFR pathway
Epidermal growth factor
Extracellular Signal-Regulated MAP Kinases - metabolism
Female
Female genital diseases
Genes
Gynecology. Andrology. Obstetrics
Hematologic and hematopoietic diseases
Humans
Investigative techniques, diagnostic techniques (general aspects)
Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis
Lymph Nodes - pathology
Lymphatic Metastasis
Medical sciences
Metastasis
Middle Aged
Mutation
Netherlands - epidemiology
Odds Ratio
Pathology
Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques
Pelvis
Phosphorylation
Prognosis
Proto-Oncogene Proteins c-akt - metabolism
PTEN Phosphohydrolase - metabolism
Radiation therapy
Receptor, Epidermal Growth Factor - metabolism
Review boards
Studies
Surgery
Survival
Survival Rate
Tissue Array Analysis
Tumors
Uterine Cervical Neoplasms - metabolism
Uterine Cervical Neoplasms - mortality
Uterine Cervical Neoplasms - pathology
Young Adult
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Summary:Summary The objective of this study is to correlate the expression of epidermal growth factor receptor (EGFR) components with clinical behavior of early-stage cervical cancer. Tissue samples of 336 consecutive Federation of International Gynecologists and Obstetricians stage IB-IIA cervical cancer patients all treated primarily by radical surgery were collected. Clinicopathologic and follow-up data were prospectively obtained during standard treatment and follow-up. As representatives for the EGFR pathway, expression of EGFR, pEGFR, PTEN, pAKT, and pERK was assessed by immunohistochemistry on tissue microarrays. Positive immunostaining was observed for EGFR in 32.1%, for pEGFR in 21.0%, for PTEN in 38.3%, for pAKT in 5.3%, and for pERK in 4.3% of tumor samples. Positive EGFR immunostaining was associated with squamous cell carcinoma of the cervix (odds ratio [OR], 7.41; 95% confidence interval [CI], 3.38-16.23, P < .001), negative pEGFR immunostaining with poor differentiation (OR, 0.39; 95% CI, 0.20-0.73, P = .004), and negative PTEN immunostaining with metastatic pelvic lymph nodes (OR, 0.51; 95% CI, 0.30-0.90, P = .019). In multivariate analysis, only pelvic lymph node metastasis (hazard ratio, 6.11; 95% CI, 3.46-10.77, P < .001) and poor differentiation (hazard ratio, 1.91; 95% CI, 1.12-3.26, P = .018) were related to disease-specific survival. In early-stage cervical cancer, loss of PTEN expression is associated with pelvic lymph node metastasis, suggesting PTEN to be one of the tumor suppressor genes affecting pelvic lymph node metastasis. However, expression of EGFR pathway components does not appear to have prognostic impact in surgically treated early-stage cervical cancer.
ISSN:0046-8177
1532-8392
DOI:10.1016/j.humpath.2010.04.017