Effects of natural progesterone on the morphology of the endometrium in patients with primary ovarian failure

In 43 patients without ovaries, endometrial biopsies at day 21 of 75 substituted cycles were studied by Light and electron microscopy. The morphology of the endometrium was compared after oral, vaginal or intramuscular administration of progesterone, and correlated with the serum levels of 17-β oest...

Full description

Saved in:
Bibliographic Details
Published in:Human reproduction (Oxford) 1990-07, Vol.5 (5), p.537-543
Main Authors: Bourgain, C., Devroey, P., Waeshberghe, L.Van, Smitz, J., Steirteghem, A.C.Van
Format: Article
Language:English
Subjects:
Administration, Oral
Embryo Transfer
endometrium
Endometrium - pathology
Estradiol - blood
Female
Fertilization in Vitro
Humans
Injections, Intramuscular
Microscopy, Electron
morphology
Ovarian Diseases - pathology
ovarian failure
Pregnancy
progesterone
Progesterone - administration & dosage
Progesterone - blood
Progesterone - therapeutic use
Vagina
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:In 43 patients without ovaries, endometrial biopsies at day 21 of 75 substituted cycles were studied by Light and electron microscopy. The morphology of the endometrium was compared after oral, vaginal or intramuscular administration of progesterone, and correlated with the serum levels of 17-β oestradiol and progesterone and the pregnancies obtained after oocyte donation. After vaginal application of micronized progesterone, endometrial morphology closely matched that of a natural cycle. This therapy was able to support two ongoing pregnancies. No adequate endometrial response was noted after oral ingestion of progesterone. The maturation of the endometrium after intramuscular injections of progesterone in oil was heterogeneous. It was concluded that the vaginal route for administering micronized progesterone can be advised as the treatment of choice in patients without ovarian function.
ISSN:0268-1161
1460-2350
DOI:10.1093/oxfordjournals.humrep.a137138