Transfusion of Phosphoenolpyruvate-treated Blood Increases Oxygen Consumption in Acute Hemorrhage

Background: Incubating blood with phosphoenolpyruvate decreases hemoglobin oxygen affinity (HOA). This study compared transfusion with phosphoenolpyruvate-treated blood and conventionally stored blood on oxygen consumption in acutely anemic dogs. Methods: Dogs underwent isovolemic hemodilution (hema...

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Bibliographic Details
Published in:The American journal of surgery 1998-06, Vol.175 (6), p.469-471
Main Authors: Cornum, Rhonda L, Martin, R.Russell, Bandy, William C
Format: Article
Language:English
Subjects:
Acute Disease
Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy
Animals
Biological and medical sciences
Blood Preservation
Blood Transfusion
Blood. Blood and plasma substitutes. Blood products. Blood cells. Blood typing. Plasmapheresis. Apheresis
Cardiac Output
Dogs
Erythrocytes - drug effects
Hematocrit
Hemodilution
Hemodynamics
Hemoglobins - analysis
Hemorrhage - blood
Hemorrhage - metabolism
Hemorrhage - physiopathology
Hemorrhage - therapy
Medical sciences
Oxygen - blood
Oxygen Consumption
Oxyhemoglobins - analysis
Phosphoenolpyruvate - pharmacology
Transfusions. Complications. Transfusion reactions. Cell and gene therapy
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Summary:Background: Incubating blood with phosphoenolpyruvate decreases hemoglobin oxygen affinity (HOA). This study compared transfusion with phosphoenolpyruvate-treated blood and conventionally stored blood on oxygen consumption in acutely anemic dogs. Methods: Dogs underwent isovolemic hemodilution (hematocrit = 10%). After 1 hour they were transfused to a hematocrit of 18% with control or phosphoenolpyruvate treated blood. Cardiac output, co-oxymetry, and hemoglobin P 50 measurements allowed calculation of oxygen consumption during anemia, and posttransfusion. Results: Hemodilution doubled cardiac output. Transfusion with phosphoenolpyruvate-treated blood allowed greater O 2 consumption than control (8.31 ± 2.1 and 3.73 ± 0.11 cc/kg/mm). There were no differences in arterial or venous pO 2 or pH; there were marked differences in HOA, measured by posttransfusion P 50 (21 ± 3 versus 47 ± 4), and mixed venous O 2 saturation. Conclusions: Decreased HOA results in increased O 2 consumption in dogs subjected to anemic hypoxia. Phosphoenolpyruvate-treated blood provides increased oxygen consumption at a similar hematocrit when compared with untreated banked blood.
ISSN:0002-9610
1879-1883
DOI:10.1016/S0002-9610(98)00083-X