A comparison of actions of neuropeptide Y (NPY) agonists and antagonists at NPY Y1 and Y2 receptors in anaesthetized rats

The pancreatic polypeptide family includes three members, neuropeptide Y (NPY), peptide YY (PYY) and pancreatic polypeptide (PP), with sequence homology between members and species varying from approximately 50 to 80%. Some of these peptides were compared in the mammalian cardiovascular system for a...

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Bibliographic Details
Published in:Neuropeptides (Edinburgh) 1998-04, Vol.32 (2), p.109-118
Main Authors: SMITH-WHITE, M, MORIARTY, M. J, POTTER, E. K
Format: Article
Language:English
Subjects:
Anesthesia
Animals
Biological and medical sciences
Cell receptors
Cell structures and functions
Dose-Response Relationship, Drug
Female
Fundamental and applied biological sciences. Psychology
Heart - innervation
Humans
Molecular and cellular biology
Neuropeptide receptors
Neuropeptide Y - analogs & derivatives
Neuropeptide Y - pharmacology
Pancreatic Polypeptide - pharmacology
Peptide Fragments - pharmacology
Peptides, Cyclic - pharmacology
Protein Precursors - pharmacology
Rats
Rats, Wistar
Receptors, Neuropeptide Y - agonists
Receptors, Neuropeptide Y - antagonists & inhibitors
Receptors, Neuropeptide Y - physiology
Recombinant Fusion Proteins - pharmacology
Salmon
Synapses - chemistry
Synapses - physiology
Vagus Nerve - drug effects
Vagus Nerve - physiology
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Summary:The pancreatic polypeptide family includes three members, neuropeptide Y (NPY), peptide YY (PYY) and pancreatic polypeptide (PP), with sequence homology between members and species varying from approximately 50 to 80%. Some of these peptides were compared in the mammalian cardiovascular system for activity mediated by actions on pre- (Y2) and post-junctional (Y1) NPY receptors. NPY and PYY, with sequence homology of 67% have similar actions on Y1 and Y2 receptors. Rat pancreatic polypeptide (rPP) with sequence homology of approximately 50% is inactive at both. This study reports that the chimeric peptide, hPP1-11/NPY12-36 and the truncated peptide NPY2-36 show similar activity to NPY mediated through both receptor types in vivo, while salmon PYY (sPYY), with 81% homology to NPY, has improved potency at both receptor subtypes. NPY3-36 has equal activity with NPY on actions mediated through Y2 receptors, but significantly reduced activity mediated through Y1 receptors. Two NPY antagonists were also examined: PYX2 was inactive in vivo and 1229U91 showed potent, long-lasting activity on Y1 receptor-mediated effects.
ISSN:0143-4179
1532-2785
DOI:10.1016/S0143-4179(98)90025-7