Interferon-γ Increases Expression of Chemokine Receptors CCR1, CCR3, and CCR5, But Not CXCR4 in Monocytoid U937 Cells

Chemokine receptors (CR), which can mediate migration of immune cells to the site of inflammation, also function as coreceptors for human immunodeficiency virus (HIV) entry into CD4+ T lymphocytes and antigen-presenting cells. We demonstrate here that interferon-γ (IFN-γ) increases the expression of...

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Bibliographic Details
Published in:Blood 1998-06, Vol.91 (12), p.4444-4450
Main Authors: Zella, Davide, Barabitskaja, Oxana, Burns, Jennifer M., Romerio, Fabio, Dunn, Daniel E., Revello, Maria Grazia, Gerna, Giuseppe, Jr, Marvin S. Reitz, Gallo, Robert C., Weichold, Frank F.
Format: Article
Language:English
Subjects:
AIDS/HIV
Antineoplastic Agents - pharmacology
Antiviral Agents - pharmacology
Biological and medical sciences
Cell Line
Cell Movement - drug effects
Fundamental and applied biological sciences. Psychology
Humans
Interferon-gamma - pharmacology
Microbiology
Monocytes - cytology
Monocytes - drug effects
Monocytes - immunology
Receptors, CCR1
Receptors, CCR3
Receptors, CCR5 - biosynthesis
Receptors, CCR5 - immunology
Receptors, Chemokine - biosynthesis
Receptors, Chemokine - immunology
Receptors, CXCR4 - biosynthesis
Receptors, CXCR4 - immunology
Replicative cycle, interference, host-virus relations, pathogenicity, miscellaneous strains
Virology
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Summary:Chemokine receptors (CR), which can mediate migration of immune cells to the site of inflammation, also function as coreceptors for human immunodeficiency virus (HIV) entry into CD4+ T lymphocytes and antigen-presenting cells. We demonstrate here that interferon-γ (IFN-γ) increases the expression of chemokine receptors CCR1, CCR3, and CCR5 in monocytoid U937 cells as detected by cell surface molecule labeling and mRNA expression, as well as by intracellular calcium mobilization and cell migration in response to specific ligands. The increased expression of these chemokine receptors also results in an enhanced HIV-1 entry into cells. Our data provide evidence for a relationship of cellular pathways that are induced by IFN-γ with those that regulate chemokine receptor expression.
ISSN:0006-4971
1528-0020
DOI:10.1182/blood.V91.12.4444